INTRODUCTION
MATERIALS AND METHODS
RESULTS
Demographic data
Preoperative imaging
Table 1.
Values are presented as number (%). Invasion : 0, sella normal; 1, sella focally expanded and tumor ≤10 mm; 2, sella enlarged and tumor ≥10 mm; 3, localized perforation of the sellar floor; 4, diffuse destruction of the sellar floor. Suprasellar extension : A, no suprasellar extension; B, anterior recesses of the third ventricle obliterated; C, floor of the third ventricle grossly displaced with parasellar extension; D, intracranial (intradural) : anterior, middle or middle fossa; E, into/beneath the cavernous sinus (extradural).
NA : not available
Postoperative results
Table 2.
3−6-month remission | Long-term remission | |
---|---|---|
Maximum tumor size | ||
Group 1, 0−5 mm (n=41) | 31 (75.6) | 33 (80.5) |
Group 2, 6−10 mm (n=24) | 22 (91.7) | 22 (91.7) |
Group 3, 10−20 mm (n=20) | 17 (85.0) | 17 (85.0) |
Group 4, >20 mm (n=11) | 4 (36.4) | 7 (63.6) |
p-value | 0.003* | 0.200 |
Knops classification | ||
0 (n=52) | 41 (78.8) | 44 (84.6) |
1 (n=22) | 21 (95.5) | 21 (95.5) |
2 (n=6) | 4 (66.7) | 3 (50.0) |
3 (n=8) | 7 (87.5) | 7 (87.5) |
4 (n=8) | 1 (12.5) | 4 (50.0) |
p-value | <0.001* | 0.010* |
Modified Hardy classification | ||
0 | ||
A (n=41) | 32 (78.0) | 34 (82.9) |
1 | ||
A (n=14) | 12 (85.7) | 12 (85.7) |
2 | ||
E (n=4) | 3 (75.0) | 3 (75.0) |
A (n=5) | 5 (100.0) | 5 (100.0) |
3 | ||
E (n=5) | 2 (40.0) | 2 (40.0) |
A (n=1) | 1 (100.0) | 1 (100.0) |
B (n=2) | 2 (100.0) | 2 (100.0) |
4 | ||
E (n=1) | 0 (0.0) | 0 (0.0) |
A (n=1) | 1 (100.0) | 1 (100.0) |
D (n=1) | 0 (0.0) | 0 (0.0) |
E (n=3) | 1 (33.3) | 3 (100.0) |
p-value | 0.10 | 0.06 |
Pathology result | ||
Corticotropinoma (+) (n=71) | 58 (81.7) | 60 (84.5) |
Corticotropinoma (-) (n=25) | 16 (64.0) | 19 (76.0) |
p-value | 0.07 | 0.30 |
Values are presented as number (%). Invasion : 0, sella normal; 1, sella focally expanded and tumor ≤10 mm; 2, sella enlarged and tumor ≥10 mm; 3, localized perforation of the sellar floor; 4, diffuse destruction of the sellar floor. Suprasellar extension : A, no suprasellar extension; B, anterior recesses of the third ventricle obliterated; D, intracranial (intradural) with anterior, middle, or middle fossa; E, into/beneath the cavernous sinus (extradural).
Day 2, Cushing’s Awareness Challenge 2022
in Cushing's Awareness Day, April 8
Posted
Even though this was from two years ago, I don't think that there have been any significant changes in the many symptoms of Cushing's.
Today's News Item proclaimed loftily
But will enough doctors actually allow patients to get that far or will they still blow them off?