This is really interesting. Since my doctor went up on my metaformin (same class of drug as the avandia), my urinary cortisols have gone down tremendously (as far as less than 2). My doc and I had attributted this to intermittent Cushings though, she said she'd never seen them go as low as that before in someone with my problems. I can't help but wonder if there might not be a connection here. What do y'all think?