Jump to content
Strawberry Orange Banana Lime Leaf Slate Sky Blueberry Grape Watermelon Chocolate Marble
Strawberry Orange Banana Lime Leaf Slate Sky Blueberry Grape Watermelon Chocolate Marble
MaryO

A ?smart? type of Cushing's syndrome

Recommended Posts

http://www.eje.org/cgi/content/abstract/157/6/779

 

DOI: 10.1530/EJE-07-0538

European Journal of Endocrinology, Vol 157, Issue 6, 779-781

Copyright ? 2007 by Society of the European Journal of Endocrinology

 

CASE REPORT

A ?smart? type of Cushing's syndrome

A J Razenberg, J W F Elte, A P Rietveld, H C T van Zaanen and M Castro Cabezas

 

Sint Franciscus Gasthuis Rotterdam, Department of Internal Medicine, Center for Diabetes and Vascular Medicine, PO Box 10900, 3004 BA Rotterdam, The Netherlands

 

(Correspondence should be addressed to M C Cabezas; Email: m.castrocabezas@sfg.nl)

 

Abstract

 

Cushing's syndrome results from lengthy and inappropriate exposure to excessive concentrations of either endogenous or exogenous glucocorticoids. This case report describes a patient with a novel type of Cushing's syndrome due to the use of party drugs. A 35-year-old woman had gained 8 kg body weight in 5 months and complained of anxiety. She showed a Cushing-like appearance and mild hypertension (blood pressure, BP 150/95 mmHg). She reported daily use of increasing doses of {gamma}-hydroxybutyric acid (GHB), a popular party drug. ACTH plasma levels were in the upper normal range (41 ng/l), with normal plasma cortisol (0.36 ?mol/l). She showed an abnormal overnight 1 mg dexamethasone suppression test (cortisol 0.38 ?mol/l). The urinary excretion of free cortisol in 24 h was also increased (0.47 ?mol/24 h). CT scanning of the abdomen showed normal adrenals. After stopping GHB intake she lost 7 kg body weight and her BP normalized (BP 135/80 mmHg). GHB is a popular party drug in the Netherlands, but it is also used as a narcotic and for the treatment of narcolepsy. We hypothesize that GHB may bind to the pituitary gland {gamma}-aminobutyric acid-B receptors leading to ACTH overproduction.

Share this post


Link to post
Share on other sites

Holy moly; my sister became debilitated and bedridden with fatigue on Xyrem. Once I looked it up and found that it suppresses cortisol, she began a very slow taper and is much better.

Share this post


Link to post
Share on other sites

Hmmm....I wonder if the use of Extasy in my wild late teens had any adverse effect on my system? Perhaps the root cause of my current medical symptoms?

Share this post


Link to post
Share on other sites

I just don't understand what is "smart" about this.

Share this post


Link to post
Share on other sites

I totally agree. Not sure where smart fits in.

 

And, cushiemom, it corrected itself right away in that person's case so it is likely not your cause.

 

Nick

Share this post


Link to post
Share on other sites

Makes me wonder if I hang out with Britney, Lindsey and Paris for a while if that will get me that last sky-high I am looking for!

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...

×
×
  • Create New...