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Provera/Depo linked to Cushings

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http://www.drugs.com/sfx/medroxyprogestero...tml#system_6203

 

Medroxyprogesterone Side Effects

Brand Names: Provera, Depo-Provera, depo-subQ provera 104, Depo-SubQ Provera 104

 

 

Please note - some side effects for Medroxyprogesterone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

 

 

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For the consumer

Medroxyprogesterone

Medroxyprogesterone Injectable Suspension

Medroxyprogesterone Injectable Suspension (subcutaneous)

 

 

For the professional

Medroxyprogesterone

 

 

By body system

Endocrine side effects

Metabolic side effects

Genitourinary side effects

Oncologic side effects

Cardiovascular side effects

Musculoskeletal side effects

Dermatologic side effects

Nervous system side effects

Gastrointestinal side effects

Hepatic side effects

Hematologic side effects

Hypersensitivity side effects

Local side effects

Ocular side effects

Psychiatric side effects

 

 

 

Side Effects of Medroxyprogesterone - for the consumer

 

 

Medroxyprogesterone

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone:

 

Acne; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain; rash; sleeplessness; stomach pain; weakness; weight gain or loss.

 

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; depression; lumps in the breast or under the armpits; partial or complete loss of vision or changes in vision; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache; swelling of fingers or ankles; tenderness, pain, or swelling of the calf; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.

 

 

 

 

Medroxyprogesterone Injectable Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone Injectable Suspension:

 

Acne; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain, redness, and swelling at injection site; sleeplessness; weakness.

 

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone Injectable Suspension:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood clots; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; chest pain; mental or mood changes; partial or complete loss of vision or changes in vision; severe dizziness or fainting; severe stomach pain; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache or vomiting; swelling of fingers or ankles; unusual weight gain or loss; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.

 

 

 

 

Medroxyprogesterone Injectable Suspension (subcutaneous)

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Medroxyprogesterone Injectable Suspension (subcutaneous):

 

Acne; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; dizziness; drowsiness; fever; headache; hot flashes; nausea; nervousness; pain; rash; sleeplessness; stomach pain; weakness; weight gain or loss.

 

Seek medical attention right away if any of these SEVERE side effects occur when using Medroxyprogesterone Injectable Suspension (subcutaneous):

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood clots; chest pain; depression; partial or complete loss of vision or changes in vision; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache; swelling of fingers or ankles; weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.

 

 

Top

 

For the professional

 

 

Medroxyprogesterone

See BOXED WARNINGS, WARNINGS, and PRECAUTIONS.

 

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

 

The following adverse reactions have been reported in women taking progestins, including Medroxyprogesterone acetate tablets, without concomitant estrogens treatment:

 

1. Genitourinary System

Abnormal uterine bleeding (irregular, increase, decrease), change in menstrual flow, breakthrough bleeding, spotting, amenorrhea, changes in cervical erosion and cervical secretions.

 

2. Breasts

Breast tenderness, mastodynia or galactorrhea has been reported.

 

3. Cardiovascular

Thromboembolic disorders including thrombophlebitis and pulmonary embolism have been reported.

 

4. Gastrointestinal

Nausea, cholestatic jaundice.

 

5. Skin

Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, alopecia and hirsutism have been reported.

 

6. Eyes

Neuro-ocular lesions, for example, retinal thrombosis, and optic neuritis.

 

7. Central Nervous System

Mental depression, insomnia, somnolence, dizziness, headache, nervousness.

 

8. Miscellaneous

Hypersensitivity reactions (for example, anaphylaxis and anaphylactoid reactions, angioedema), rash (allergic) with and without pruritus, change in weight (increase or decrease), pyrexia, edema/fluid retention, fatigue, decreased glucose tolerance.

 

The following additional adverse reactions have been reported with estrogen and/or progestin therapy.

 

1. Genitourinary System

Abnormal uterine bleeding/spotting, or flow; breakthrough bleeding; spotting; dysmenorrheal/pelvic pain; increase in size of uterine leiomyomata; vaginitis, including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.

 

2. Breasts

Tenderness, enlargement, pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.

 

3. Cardiovascular

Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.

 

4. Gastrointestinal

Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis; enlargement of hepatic hemangiomas.

 

5. Skin

Chloasma or melasma that may persist when drug is discontinued; erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.

 

6. Eyes

Retinal vascular thrombosis, intolerance to contact lenses.

 

7. Central Nervous System

Headache; migraine; dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.

 

8. Miscellaneous

Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; arthalgias; leg cramps; changes in libido; urticaria, angioedema, anaphylactoid/anaplylactic reactions; hypocalcemia; exacerbation of asthma; increased triglycerides.

 

Top

 

By body system

 

 

Endocrine side effects

Cushing's syndrome is uncommon and appears to be associated with a long duration of therapy and moderate to high doses of medroxyprogesterone. Doses used for hormonal replacement therapy and for long-term contraception are not associated with Cushing's syndrome.

 

Medroxyprogesterone has mild glucocorticoid activity. In cases of medroxyprogesterone-induced Cushing's syndrome, low cortisol and adrenocorticotrophic hormone (ACTH) levels with a reduced pituitary-adrenal reserve have been documented. Acute adrenal insufficiency may ensue following withdrawal of medroxyprogesterone.

 

Endocrine side effects have included breast tenderness, galactorrhea with or without hyperprolactinemia, prevention of lactation, hirsutism, and Cushing's syndrome.

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There is a whole thread on here about depo and Cushing's. I had my tumor show up beforehand, but it was only after the depo that my symptoms went, well, all to heck...and my weight went totally out of control. Of course, it was all my fault. My gyne told me I should take up tennis (true story).

 

Old thread -

http://cushings.invisionzone.com/index.php...hl=depo+provera

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Thanks for posting this. My friend Kelly had 3 shots when she was 17. She strongly believes that depro could be the root of her medical issues. As of now she is undiagnosed. The fist 2 shots she had the "typical" side effects. The 3rd one she began the 100lb weight gain over a 3 month period. Over the last year me and another friend of ours has been digging up information on Cushing's and depro. She more than fits the signs and symptoms and had done the testing. The one pos test is "not high enough" according to one doc she saw.

 

She took the shots because her friend at the time said its great and very safe. She talked it over with the doc at the clinic and her mom, and decided to try it out. Know knowing that Cushing's can be linked to depro, she is strongly against recommending this form of bc to anyone who is thinking about it. She has mentioned this link to the doctors she has seen and only one even acknowleged this side effect.

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Depo seemed to jump start my symptoms too.

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I know in my heart the Depo started all of my symptoms. I was 100% healthy before I started Depo shots. I mean no health problems at all. None.

 

Flash foward 12 years...

 

* Hundreds of tests

* Several doctors

* Years of feeling sick, thousands of dollars spent, loss of so many things

* Unsuccessful pit surgery

* 10 months post BLA - AND STILL NOT BETTER. NOT AT ALL!!!

 

It's so strange that this topic came about again today and here is why:

 

I am currently testing for rest tissue or an ectopic source. I changed from hydro to dex for 3 days so we could see if I am making any cortisol on my own. Day one of dex I didn't feel any different. Day two of dex I started to get these awful, awful sharp pains in my right ovary area. They were so bad that I was doubled over in pain. The third day of dex was much worse with pains in the area. Day one back to hydro and no dex - pains gone. This is just my "own theory" but I can't help but wonder if I have an ectopic source on my ovaries. I've been saying since day one that depo caused my Cushing's.

 

Is Depo still available or have they yanked it from the market?

 

I'm really surprised there isn't some kind of class action law suit against the manufacturer (Pfizer).

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I definitely had cushing's symptoms for years before this, but I did seem to get worse after starting depo.

 

Unfortunately I seem to have endometriosis so I'm much sicker OFF the depo than on it... but I will be going off of it and onto lupron so we will see what happens then I guess.

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Oh my god. I am shocked.

I only did depo for about a year, but that is when all of my symptoms started. 4 years later and I have almost every symptom of classic cushings. I feel like this will just be too hard to convince my doc...

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