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  2. Abstract Background Subclinical Cushing’s disease (SCD) is defined by corticotroph adenoma-induced mild hypercortisolism without typical physical features of Cushing’s disease. Infection is an important complication associated with mortality in Cushing’s disease, while no reports on infection in SCD are available. To make clinicians aware of the risk of infection in SCD, we report a case of SCD with disseminated herpes zoster (DHZ) with the mortal outcome. Case presentation An 83-year-old Japanese woman was diagnosed with SCD, treated with
  3. The FDA accepted for review a new drug application for the steroidogenesis inhibitor levoketoconazole for the treatment of endogenous Cushing’s syndrome, according to an industry press release. “We are pleased with the FDA’s acceptance for filing of the Recorlev new drug application,” John H. Johnson, CEO of Strongbridge Biopharma, said in the release. “We believe this decision reflects the comprehensive clinical evidence that went into the NDA submission, including the positive and statistically significant efficacy and safety results from the multinational phase 3 SONICS and LOGICS stud
  4. This is a 30 min Online Survey and Compensation is $50.00 Sign up at the link below to receive an email invite to the study and see if you qualify https://rarepatientvoice.com/CushingsHelp/
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  6. Prayers and much love to Cushies who have lost their mothers, to friends who have lost their child, to friends who gave their child the amazing gift of adoption and can not celebrate today with their babies, and to our precious friends who have not been able to have a child yet, you are all precious in God’s eyes. May each of you feel His peace this weekend.

  7. Decreased visual functions and severe headache may be signs of a brain tumor. The pituitary gland is a pea-sized gland located in the bone structure at the base of the brain called Sella Turcica. The pituitary gland, which has a great effect on our body, is a vital organ that regulates the secretion of many hormones such as growth hormone, prolactin hormone, and thyrotropin. Head of Department of Brain and Nerve Surgery, Yeni Yüzyıl University Gaziosmanpaşa Hospital, Assoc. Dr. Mete Karatay said, 'Tumors in the pituitary gland cause many disorders. Therefore, the symptoms should
  8. Abstract Background: Cushing’s syndrome is a condition caused by excessive glucocorticoid with insomnia as one of its neuropsychiatric manifestation. Cushing’s syndrome may be caused by excessive adrenocorticotropin hormone (ACTH-dependent), for example from ACTH producing pituitary tumors, or by overproduction of cortisol by adrenocortical tumors. In this report, we presented a case with Cushing’s syndrome manifesting as chronic insomnia with adrenal cortical adenoma and pituitary microadenoma. Case presentation: A 30-year-old woman was consulted from the Neurologic Department to th
  9. Please note that if you buy through links in this article, Medical News Today may earn a small commission. Here’s their process. Cortisol is a hormone with various functions throughout the body. However, if a person’s body cannot regulate their cortisol levels, it could lead to a serious health condition. In these cases, home cortisol tests may be useful to indicate when someone might need medical attention. This article discusses: what cortisol is what a home cortisol test is why a person might buy a home cortisol test some home cortisol tests to purchase
  10. Highlights • There is a highs suspicion of acute pancreatitis complications for patients with Cushing syndrome. • Corticosteroids are a common cause for both Cushing syndrome and acute pancreatitis. • There are many common etiologies between Cushing syndrome and acute pancreatitis. • Cushing syndrome is a risk factor of acute pancreatitis, need further detailed studies. Abstract Introduction Cushing's syndrome (CS) is a r
  11. And it is a Squamous Cell Carcinoma :(  Mohs Surgery on Monday.  Drat!  Just Nosing Around

  12. This month marks a little over one year since the first surge of COVID-19 across the United States. April is also Adrenal Insufficiency Awareness month, a good time to review the data on how COVID-19 infection can impact the adrenal glands. The adrenal glands make hormones to help regulate blood pressure and the ability to respond to stress. The hormones include steroids such as glucocorticoid (cortisol), mineralocorticoid (aldosterone), and forms of adrenaline known as catecholamines (norepinephrine, epinephrine, and dopamine). The activity of the adrenal gland is controlled throug
  13. Biopsy yesterday - they're thinking it's a squamous cell carcinoma.  Drat! 

  14. MaryO

    Advice

    Donkey, I am so sorry to read all that you've been through. Getting a Cushing's diagnosis is the worst, especially when doctors don't believe us. You didn't know what kind of doctor you have that doubts you have Cushing's but it sounds like you need another. Your best choice would be an endocrinologist who has had other Cushing's patients. Even though you aren't obese with striae...not every person has every symptom. The only way to diagnose Cushing's is with testing, not by a list of symptoms. Best of luck to you. I hope you keep us posted on your progress!
  15. Guest

    Advice

    Hello good people. Bear with me. 🐻 So i think I maybe have Cushings. For 3 years now I have been feeling tired, with muscle and joint pain, fatigue.also diabetes insipidus ( I think, excessive thirst and urination) and excessive brusing on legs. My period stoped for a year or so after the pill. That's when I started looking for a couse. My doctor gave me metformin for my period wich helped as my period was back and regular. Also I noticed circulation problems. Have been reading a lot about Cushings and I have almost all sympoms except striae and I'm not entirely overweight but I gained
  16. Excess mortality among people with endogenous Cushing syndrome (CS) has declined in the past 20 years yet remains three times higher than in the general population, new research finds. Among more than 90,000 individuals with endogenous CS, the overall proportion of mortality ― defined as the ratio of the number of deaths from CS divided by the total number of CS patients ― was 0.05, and the standardized mortality rate was an "unacceptable" three times that of the general population, Padiporn Limumpornpetch, MD, reported on March 20 at ENDO 2021: The Endocrine Society Annual Meeting.
  17. Updates on Treating Hypothyroidism Dr. Theodore Friedman will be giving a webinar on Updates on Treating Hypothyroidism. Topics to be discussed include: New articles showing patients prefer desiccated thyroid New thyroid hormone preparations Update on desiccated thyroid recalls New article on why TSH is less important than thyroid hormone measurements What is the difference between desiccated thyroid and synthetic thyroid hormones? Is rT3 important? Sunday • April 25• 6 PM PDT Via Zoom Click here to join the meeting or https://us02web.zoo
  18. Updates on Treating Hypothyroidism Dr. Theodore Friedman will be giving a webinar on Updates on Treating Hypothyroidism. Topics to be discussed include: New articles showing patients prefer desiccated thyroid New thyroid hormone preparations Update on desiccated thyroid recalls New article on why TSH is less important than thyroid hormone measurements What is the difference between desiccated thyroid and synthetic thyroid hormones? Is rT3 important? Sunday • April 25• 6 PM PDT Via Zoom Click here to join the meeting or https://us02web.zoo
  19. until
    I plan to do the Cushing's Awareness Challenge again. A past year info is here: https://cushieblogger.com/2018/03/11/time-to-sign-up-for-the-cushings-awareness-challenge-2018/ The original page is getting very slow loading, so I've moved my own posts to this newer blog. As always, anyone who wants to join me can share their blog URL with me and I'll add it to the links on the right side, so whenever a new post comes up, it will show up automatically. If the blogs are on WordPress, I try to reblog them all to get even more exposure on the blog, on Twitter and on Facebook at Cush
  20. Some of the latest research advancements in the field of endocrinology presented at the Endocrine Society's virtual ENDO 2021 meeting included quantifying diabetic ketoacidosis readmission rates, hyperglycemia as a severe COVID-19 predictor, and semaglutide as a weight loss therapy. Below are a few more research highlights: More Safety Data on Jatenzo In a study of 81 men with hypogonadism -- defined as a serum testosterone level below 300 ng/dL -- oral testosterone replacement therapy (Jatenzo) was both safe and effective in a manufacturer-sponsored study. After 24 months
  21. Zarina Brady, Aoife Garrahy, Claire Carthy, Michael W. O’Reilly, Christopher J. Thompson, Mark Sherlock, Amar Agha & Mohsen Javadpour BMC Endocrine Disorders volume 21, Article number: 36 (2021) Cite this article 160 Accesses Metricsdetails Abstract Background Transsphenoidal surgery (TSS) to resect an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is the first-line treatment for Cushing’s disease (CD), wi
  22. A large study of mortality in Cushing’s syndrome calculated a threefold higher mortality rate for these patients, with cerebrovascular and atherosclerotic vascular diseases and infection accounting for 50% of deaths, researchers reported. “[We have seen] improvement in outcome since 2000, but mortality is still unacceptably high,” Padiporn Limumpornpetch, MD, an endocrinologist at Prince of Songkla University in Thailand and PhD student at the University of Leeds, U.K., told Healio during the ENDO annual meeting. “The mortality outcome has shown an unacceptable standardized mortality rate
  23. Adrenal insufficiency increases the risk for severe outcomes, including death, 23-fold for children who contract COVID-19, according to a data analysis presented at the ENDO annual meeting. “Adrenal insufficiency in pediatrics does increase risk of complications with COVID-19 infections,” Manish Gope Raisingani, MD, assistant professor in the department of pediatrics in the division of pediatric endocrinology at Arkansas Children's Hospital, University of Arkansas for Medical Sciences, told Healio. “The relative risk of complications is over 20 for sepsis, intubation and mortality, which
  24. Here's your chance to make your voice heard on Growth Hormone Issues. Anyone interested would sign up with Rare Patient Voice using the CushingsHelp referral Link. You would then get an email invite to the actual study. Study Opportunity for Idiopathic Short Stature (ISS) Caregivers This is a 30 min online survey and Compensation is $50 Please sign up at the link below for more information or to see if you qualify https://rarepatientvoice.com/CushingsHelp/
  25. WASHINGTON--Endogenous Cushing's syndrome, a rare hormonal disorder, is associated with a threefold increase in death, primarily due to cardiovascular disease and infection, according to a study whose results will be presented at ENDO 2021, the Endocrine Society's annual meeting. The research, according to the study authors, is the largest systematic review and meta-analysis to date of studies of endogenous (meaning "inside your body") Cushing's syndrome. Whereas Cushing's syndrome most often results from external factors--taking cortisol-like medications such as prednisone--the endoge
  26. John P H Wilding 1 Affiliations expand PMID: 32061161 DOI: 10.1530/EJE-20-0099 Abstract Endocrine disorders such as Cushing's syndrome and hypothyroidism may cause weight gain and exacerbate metabolic dysfunction in obesity. Other forms of endocrine dysfunction, particularly gonadal dysfunction (predominantly testosterone deficiency in men and polycystic ovarian syndrome in women), and abnormalities of the hypothalamic-pituitary-adrenal axis, the growth hormone-IGF-1 system and vitamin D deficiency are common in obe
  27. There is an absence of online information regarding the risks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nasopharyngeal swab (NPS) testing for patients with a history of sinus and/or pituitary surgery, according to a research letter published online March 4 in JAMA Otolaryngology-Head & Neck Surgery. Noting that blind NPS testing poses a risk to patients with sinus pathology, Taylor Fish, from the University of Texas Health San Antonio, and colleagues examined online preoperative and postoperative patient information regarding the potential risks of SARS-CoV-2 NPS
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