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Everything posted by zhen

  1. It's more complicated than a cure rate. There's a comprehensive report about the success and adverse event rates on the fda website. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM326812.pdf
  2. The full text article can be found at: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000314299&Ausgabe=254530&ProduktNr=223855&filename=000314299.pdf
  3. I think anything that gives an early warning of AI would be highly desirable, even if it's not perfect or useful for clinical diagnosis. Forty years ago, we would pee on a paper strip to learn of glucose was spilling. It wasn't as powerful as glucometers, but it was lifesaving.
  4. hope, do you think endocrine tumors may run in your family?
  5. Their limit of 38 nmol/L is the same as a limit of 1.38 ug/dL. (38/27.6=1.38) Your report is in ug/mL so their limit in the same units as your report would be 0.138 ug/mL. You're over limit at 0.5 ug/mL. Conversion of their limit is from nmol/L to ug/dL is accomplished by dividing by 27.6. They reported in mL instead of dL, so move the decimal one place. Another way to look at this is you were 5 ug/dL (0.5 ug/mL) which is larger than 1.38 ug/dL. Working the other way, your 0.5 ug/mL would convert to 138 nmol/L ( 0.5 ug/mL * 27.6 * 10 = 138) 138 is way larger than 38 = cushing's.
  6. Corlux is getting closer to approval. Corcept Therapeutics Submits NDA for Corlux in Cushing?s Syndrome
  7. Trepanation can be good for you.

  8. I read somewhere, can't remember where, that dopamine is transported down the pituitary stalk. If so, what is the connection?
  9. The problem is that dopamine agonist pose the risk of heart valve damage and pulmonary hypertension.
  10. zhen

    forget the docs and the labs. Just be kind to yourself. Things will get better. Make youself a plan. Set some small goals.. hope your better soon

  11. I monitor skype when I'm online.


  12. Inbox is like my garage. It needs some cleaning.

  13. Finished testing. Diagnosis positive.

  14. I think the alternate use and cost of mifaprisone will keep it out of reach. There's a phase IIb report on INCB13739 at: Phase IIB results I was impressed enough to buy 1000 shares of Incyte because I believe this will lead to weight loss for type II's. The use in Cushing's, if any would be small compared with use for type II diabetes. I also called and asked how to enroll in phase III, but the answer to that was "not yet". I hadn't read about ACTH causing inflammation. I'll look into that. It did cause ACTH rise, but feedback was maintained. Twelve weeks is not long enough to sort out side effects from that. I think ACTH can stimulate aldosterone release. If that happens, MR receptors need to be blocked too because aldosterone acts on heart muscle and artery walls to cause hypertrophy. In pituitary cushing's, would this have any effect on ACTH anyway? The ACTH comes from the adenoma without regard to cortisol. It modulates cortisol by preventing cortisone > cortisol conversion by 11bsd1. It doesn't directly effect insulin secretion. By modulating cortisol, it treats metabolic resistance. That's a key feature of Cushing's. That's why I'm optimistic it has a place here.
  15. There's a drug in the pipeline that could help. Incyte is through phase II on a product labeled INCB13739 for type 2 diabetes. It works by inhibiting conversion of cortisone to cortisol by inhibiting 11-beta hydroxysteroid dehydrogenase. Incyte
  16. There's an excellent journal article at: Endocrine disrupters as obesogens
  17. Virus has been speculated as causal for fibromyalgia and chronic fatigue syndrome nearly since the outbreak at Incline Village, Nevada in 1984. About CFS Website More recently it was discovered by Whittemore Peterson clinic that a retrovirus called XMRV is associated with CFS. The announcement was October 2009. WP Institute Website A new study from Sweden ascribes Fibromyalgia as being caused by HYPOcortisolism. This is opposite of Cushing's. Pubmed I think you should keep your date with camp cushings. If you find a proven adenoma that causes hypercortisolism, it's not going to be fixed by taking anti-inflammatory medications. You'll end up suffering an additional six months for nothing. The problem is that symptoms of fatigue, muscle aches, brain fog and so forth are non-specific. Many conditions have the same constellation of symptoms. If you get put in the wrong bin because your symptoms are similar to other patients, you won't get better. We could turn this around and say fix the Cushings. Then the immune system will control the HSV....
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