BDen13

I only suggested the 24 Hour UFC since it's a different test and if both Midnight Salivaries came back high I'm guessing the 24 Hour UFC would too. Even endocrinologists who know the disease like at least two different types of tests to come back abnormal before giving a diagnosis. I don't think it's a be-all-end-all test either because it doesn't take into account the lack of diurnal rhythm (you could be normal in the morning, then high in the evening and the 24 hour total could still come back high-normal, yet still have cushing's).

hmm, 2 out of 2 high Midnight Cortisols is getting close enough for diagnosis by a proper endocrinologist. I would ask for a 24 Hour Urinary Free Cortisol - if that comes back high too that should definitely be enough for a diagnosis. Your current doctor is not using or interpreting the Dex Suppression test properly - if you did suppress, that just rules out adrenal cushing's. You could still have pituitary cushing's, which is more likely anyway.

Sagrae, from those tests I see nothing to suggest that you have cushing's and in fact your saliva tests would indicate addison's disease. The good news about Addison's is that it can be treated with medication. Show your doctor your Salivary cortisol results and ask for a prescription for hydrocortisone pills and see if they make you feel better. However I wouldn't rule out a thyroid problem either as those results are somewhat suspect as well. Hypothyroidism could result in the weight gain you complain of - it can also be treated with medication.

A lot of your symptoms are consistent with cushing's and some of them are not or in fact contraindicate it. Rather than cushing's you could have Thyroid or other endocrine that could be causing many of your current symptoms. Have you ever seen an endocrinologist? Have you ever had blood tests run that measure your hormones and metabolic chemicals? That would be a good place to start.

What blood tests did you have? The tests that are typically used to diagnose Cushing's are the 24 Hour Urinary Cortisol test and the Midnight Salivary Cortisol test. If you see the endocrinologist in the afternoon a blood serum cortisol test is inexpensive and easy, but isn't enough to rule the disease in or out. Blood serum cortisol taken in the morning is essentially worthless. Have you made your endocrinologist appointment yet? It's important that you talk to one that specializes in cushing's syndrome or is at least familiar with it (steer clear of endocrinologists whose profiles talk a lot about diabetes, most of them know nothing about pituitary disorders). If you tell us where you live we can help you find one. Have you been told that you have high blood pressure by any of your doctors? Also, have any of the doctors checked your potassium levels? Those are two dangerous things that Cushing's can cause that you can treat medically before Cushing's is treated surgically (if that's what you have). You say you have low blood pressure - that's quite odd if you do have Cushing's.