Report Cortisol / Cushings / Addisons / Cymbalta in Guest Questions Posted July 6, 2012 I took one pill of Cymbalta for my Fibromyalgia and it threw me into an adrenal crisis. I had Cushing's, had pituitary surgery, then a bilateral adrenalectomy, leaving me with Addison's. I take hydrocortisone every day to stay alive. Most of the time I have no trouble, but that Cymbalta threw me for a loop. I had major bad diarrhea, nausea, dizziness, foggy brained, and I think I had a headache. I was a mess! As Melly said, you could be cyclical, and sometimes we go from one extreme to the other. It can be pretty brutal at times!