Report We Have Too Many Cortisol Receptors in News Items and Research Posted August 16, 2010 Aha! I remember that study! It talked about faulty development of the HPA and how the axis would be expecting more cortisol thanks to childhood trauma. This explains so much. That fits my childhood and teen years, too. But I also have the complications resulting from my dad's Agent Orange exposure and the signs and symptoms I was born with that Endos like Dr. F found interesting. I think it bolsters the childhood trauma theory. Our receptors are screwed up because they were taught from a young age to expect unusually high levels of stress. That fits with my childhood and teen years.