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  1. Treatment with fluconazole after cabergoline eased symptoms and normalized cortisol levels in a patient with recurrent Cushing’s disease who failed to respond to ketoconazole, a case study reports. The case report, “Fluconazole as a Safe and Effective Alternative to Ketoconazole in Controlling Hypercortisolism of Recurrent Cushing’s Disease: A Case Report,” was published in the International Journal of Endocrinology Metabolism. Ketoconazole, (brand name Nizoral, among others) is an anti-fungal treatment used off-label for Cushing’s disease to prevent excess cortisol production, a dis
  2. Minimally invasive diagnostic methods and transnasal surgery may lead to remission in nearly all children with Cushing’s disease, while avoiding more aggressive approaches such as radiation or removal of the adrenal glands, a study shows. The study, “A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations,” was published in the Journal of Pediatric Endocrinology and Metabolism. Normally, the pituitary produces adrenocorticotropic hormone (ACTH), which
  3. We have a new form to add your own bio! Try it out here: https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/ Thank you for submitting your bio - sometimes it takes a day or so to get them formatted for the website and listed on the pages where new bios are listed. If you are planning to check the button that reads "Would you like to be considered for an interview? (Yes or No)" please be sure to read the Interview Page for information on how these interviews work. Please do not ask people to email you answers to your questions. Your question is probably of interest to other
  4. A plasma adrenocorticotropic hormone suppression test performed shortly after surgical adenomectomy may accurately predict both short- and long-term remission of Cushing’s disease, according to research published in Pituitary. “Cushing’s disease is caused by hypersecretion of adrenocorticotropic hormone (ACTH) by a pituitary adenoma, resulting in hypercortisolism,” Erik Uvelius, MD, of the department of clinical sciences, Skåne University Hospital, Lund University, Sweden, and colleagues wrote in the study background. “Surgical adenomectomy is the first line of treatment. Postoperative re
  5. Kayln was only 41 when she died on June 28, 2017. She had recently had pituitary surgery. Read more at https://cushingsbios.com/2017/06/28/in-memory-kayln-allen-june-28-2017/
  6. Sarah had recently had surgery to remove a tumor from her pituitary gland in the hopes of treating her Cushing’s Disease. She died on June 13, 2011 after a brief illness at the age of 28. Read more at https://cushingsbios.com/2013/09/14/sarah-fraik/
  7. until
    Join us on Saturday, October 13, 2018 10th Annual Johns Hopkins Pituitary Patient Day Saturday, October 13, 2018, 9:00 a.m. to 3:00 p.m. Location: Johns Hopkins Mt. Washington Conference Center 5801 Smith Avenue Baltimore, MD 21209 map and directions Attendance and parking are free, but seating is limited. Reserve your space now: Please R.S.V.P. by email (preferred) to PituitaryDay@jhmi.edu or by calling 410-670-7259. Agenda 9:00 - 9:25 a.m.: Registration 9:25 - 9:30 a.m.: Welcome and acknowledgments (Roberto Salvatori, M.D.) 9:30 - 10:00 a.m.: Symptom
  8. Presented By Daniel Prevedello, MD Professor, Department of Neurological Surgery Director, Minimally Invasive Cranial Surgery Program Co-Director, Comprehensive Skull Base Center at The James Director, Pituitary Surgery Program The Wexner Medical Center at The Ohio State University After registering you will receive a confirmation email with details about joining the webinar. Contact us at webinar@pituitary.org with any questions or suggestions. Date: May 8, 2018 Time: 3:00 - 4:00 PM Pacific Daylight Time, 6:00 - 7:00 PM Eastern Daylight Time Webi
  9. Presented By Daniel Prevedello, MD Professor, Department of Neurological Surgery Director, Minimally Invasive Cranial Surgery Program Co-Director, Comprehensive Skull Base Center at The James Director, Pituitary Surgery Program The Wexner Medical Center at The Ohio State University After registering you will receive a confirmation email with details about joining the webinar. Contact us at webinar@pituitary.org with any questions or suggestions. Date: May 8, 2018 Time: 3:00 - 4:00 PM Pacific Daylight Time, 6:00 - 7:00 PM Eastern Daylight Time Webi
  10. Children with Cushing’s syndrome are at risk of developing new autoimmune and related disorders after being cured of the disease, a new study shows. The study, “Incidence of Autoimmune and Related Disorders After Resolution of Endogenous Cushing Syndrome in Children,” was published in Hormone and Metabolic Research. Patients with Cushing’s syndrome have excess levels of the hormone cortisol, a corticosteroid that inhibits the effects of the immune system. As a result, these patients are protected from autoimmune and related diseases. But it is not known if the risk rises after their
  11. Erica was a fellow Cushing’s Disease survivor. She had been through pituitary surgery, radiation, and a BLA in an effort to receive her cure. Read more at https://cushingsbios.com/2015/03/11/in-memory-erica-michelle-gaga-meno/
  12. until
    Pituitary Patient Support Group Saturday March 24, 2018 Pejman Cohan, MD 10:00am - 11:45am Daniel F. Kelly, MD 11:45am - 12:45pm Lunch 1:00pm - 2:00pm Family and friends welcome Please RSVP to Sharmyn Mcgraw pituitarybuddy@hotmail.com
  13. The chemotherapy temozolomide partially improved a case of an aggressive pituitary tumor that caused symptoms of Cushing’s disease (CD), according to a new study in Poland. However, after tumor mass and cortisol levels were stabilized for a few months, the patient experienced rapid progression, suggesting that new methods for extending the effects of temozolomide are needed. The study, “Temozolomide therapy for aggressive pituitary Crooke’s cells corticotropinoma causing Cushing’s Disease: A case report with literature review,” appeared in the journal Endokrynologia Polska. Aggressiv
  14. Patients with different subtypes of Cushing’s syndrome (CS) have distinct plasma steroid profiles. This could be used as a test for diagnosis and classification, a German study says. The study, “Plasma Steroid Metabolome for Diagnosis and Subtyping Patients with Cushing Syndrome,” appeared in the journal Clinical Chemistry. A quick diagnosis of CS is crucial so that doctors can promptly give therapy. However, diagnosing CS is often complicated by the multiple tests necessary not just to diagnose the disease but also to determine its particular subtype. Cortisol, which leads to C
  15. Addison’s disease: Hyperpigmentation is a classic symptom of Addison’s disease, an endocrine disorder in which the adrenal glands fails to produce steroid hormone. The disease causes darkening of the skin in certain areas. Cushing’s syndrome: The abnormal amount of cortisol in the human body causes a condition known as the Cushing’s syndrome. And one of the symptoms of the disorder is hyperpigmentation of the skin. Adapted from http://www.thehealthsite.com/diseases-conditions/health-conditions-that-can-cause-hyperpigmentation/
  16. All patients who undergo removal of one adrenal gland due to Cushing’s syndrome (CS) or adrenal incidentaloma (AI, adrenal tumors discovered incidentally) should receive a steroid substitutive therapy, a new study shows. The study, “Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH‐independent hypercortisolism,” was published in the Journal of Endocrinological Investigation. CS is a rare disease, but subclinical hypercortisolism, an asymptomatic condition characterized by mild cortisol excess, has a much higher prevalence. In fact, subclinical hype
  17. until
    Presented by Kenneth M. De Los Reyes MD, MSc Assistant Professor Co-director of Skull Base Surgery Director of Quality Assurance Department of Neurosurgery Loma Linda University Medical Center Register Now! After registering you will receive a confirmation email with details about joining the webinar. Contact us at webinar@pituitary.org with any questions or suggestions. Date: Wednesday, December 13, 2017 Time: 10:00 AM - 11:00 AM Pacific Standard Time 1:00 PM - 2:00 PM Eastern Standard Time Webinar Description Learning Objectives: Building Pati
  18. Presented by Kenneth M. De Los Reyes MD, MSc Assistant Professor Co-director of Skull Base Surgery Director of Quality Assurance Department of Neurosurgery Loma Linda University Medical Center Register Now! After registering you will receive a confirmation email with details about joining the webinar. Contact us at webinar@pituitary.org with any questions or suggestions. Date: Wednesday, December 13, 2017 Time: 10:00 AM - 11:00 AM Pacific Standard Time 1:00 PM - 2:00 PM Eastern Standard Time Webinar Description Learning Objectives: Building Pati
  19. People with high cortisol levels have lower muscle mass and higher visceral fat deposits, putting them at a greater risk for cardiovascular disease, new research shows. High levels of cortisol can result from a variety of reasons, including Cushing’s disease and adrenal tumors. Most adrenal tumors are found to be non-functioning, meaning they do not produce excess hormones. However, up to 47 percent of patients have mild autonomous cortisol excess (MACE). The study, “Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas,” was pub
  20. ISRCTN71291784 DOI 10.1186/ISRCTN71291784 A study to investigate the prevalence of pituitary gland dysfunction and it's risk factors following traumatic brain injuries (TBI) Condition category Nervous System Diseases Date applied 28/08/2017 Date assigned 14/09/2017 Last edited 14/09/2017 Prospective/Retrospective Prospectively registered Overall trial status Ongoing Recruitment status Not yet recruiting
  21. By Tori Rodriguez, MA, LPC In the early 20th century, the term "pluriglandular syndrome" was coined by Harvey Cushing to describe the disorder that results from chronic tissue exposure to excessive levels of glucocorticoids.1 Now called Cushing's syndrome, the condition affects an estimated 10-15 million people annually, most often women and individuals between the ages of 20 and 50 years.2 Risk factors and common comorbidities include hypertension, obesity, osteoporosis, uncontrolled diabetes, depression, and anxiety.3 Presentation The clinical presentation of the disorder
  22. Abstract Objective Cushing's disease (CD) is a rare endocrine disorder characterized by excess secretion of ACTH due to a pituitary adenoma. Current treatment options are limited and may pose additional risks. A literature review was conducted to assess the holistic burden of CD. Design Studies published in English were evaluated to address questions regarding the epidemiology of CD, time to diagnosis, health-related quality of life (HRQoL), treatment outcomes, mortality, prevalence of comorbidities at diagnosis, and reversibility of comorbidities following the treatm
  23. CLCI699C2302: A Phase III, Multi-center, Randomized, Double-blind, 48 Week Study with an Initial 12 Week Placebo-controlled Period to Evaluate the Safety and Efficacy of Osilodrostat in Patients with Cushing’s Disease Purpose In people with a disorder known as Cushing’s disease, levels of the hormone cortisol are very high in the urine and blood. Lowering cortisol levels relieves the symptoms of Cushing’s disease. Osilodrostat is an investigational drug that inhibits an enzyme needed for co
  24. until
    Presented by Linda M. Rio, M.A., MFT After registering you will receive a confirmation email with details about joining the webinar. Contact us at webinar@pituitary.org with any questions or suggestions. DATE: July 17, 2017 TIME: 10:00 AM - 11:00 AM Pacific Daylight Time/1:00 PM - 2:00 PM Eastern Daylight Time Webinar Learning Objectives: By attending this webinar participants will: Be able to identify at least 3 mental health symptoms that are common to those diagnosed with a pituitary disorder. Understand basics of “trauma” and its pote
  25. Today is the anniversary of MaryO's pituitary surgery at NIH in 1987. Read more at https://cushingsbios.com/2016/11/03/29-years-giving-thanks/
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