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John P H Wilding 1 Affiliations expand PMID: 32061161 DOI: 10.1530/EJE-20-0099 Abstract Endocrine disorders such as Cushing's syndrome and hypothyroidism may cause weight gain and exacerbate metabolic dysfunction in obesity. Other forms of endocrine dysfunction, particularly gonadal dysfunction (predominantly testosterone deficiency in men and polycystic ovarian syndrome in women), and abnormalities of the hypothalamic-pituitary-adrenal axis, the growth hormone-IGF-1 system and vitamin D deficiency are common in obesity. As a result, endocrinologists may be referred people with obesity for endocrine testing and asked to consider treatment with various hormones. A recent systematic review and associated guidance from the European Society of Endocrinology provide a useful evidence summary and clear guidelines on endocrine testing and treatment in people with obesity. With the exception of screening for hypothyroidism, most endocrine testing is not recommended in the absence of clinical features of endocrine syndromes in obesity, and likewise hormone treatment is rarely needed. These guidelines should help reduce unnecessary endocrine testing in those referred for assessment of obesity and encourage clinicians to support patients with their attempts at weight loss, which if successful has a good chance of correcting any endocrine dysfunction. Similar articles Classical endocrine diseases causing obesity. Weaver JU.Front Horm Res. 2008;36:212-228. doi: 10.1159/000115367.PMID: 18230905 Review. Is obesity an endocrine condition? Stocks AE.Aust Fam Physician. 1977 Feb;6(2):109-16.PMID: 558747 FPIN’s clinical inquiries. Secondary causes of obesity. Allen G, Safranek S.Am Fam Physician. 2011 Apr 15;83(8):972-3.PMID: 21524038 No abstract available. [Role of the endocrine system in the pathogenesis of non-alcoholic fatty liver disease]. Hagymási K, Reismann P, Rácz K, Tulassay Z.Orv Hetil. 2009 Nov 29;150(48):2173-81. doi: 10.1556/OH.2009.28749.PMID: 19923096 Review. Hungarian. Obesity and endocrine disease. Kokkoris P, Pi-Sunyer FX.Endocrinol Metab Clin North Am. 2003 Dec;32(4):895-914. doi: 10.1016/s0889-8529(03)00078-1.PMID: 14711067 Review. From https://pubmed.ncbi.nlm.nih.gov/32061161/