Chief Cushie ~MaryO~ Posted April 28, 2007 Chief Cushie Report Share Posted April 28, 2007 http://www.aemj.org/cgi/content/full/14/5_Supplement_1/S125 Acad Emerg Med Volume 14, 5 Supplement 1 125, ? 2007 Society for Academic Emergency Medicine The Use of Cortisol as an Early Marker for Acute Myocardial Infarction in an Emergency Department Setting John Gough, Velvet Patterson and Kori Brewer Brody School of Medicine Background Acute myocardial infarction is traditionally confirmed or ruled out using EKG and cardiac enzymes. However, these tests may be nonspecific and time dependent, delaying intervention. It is important to continue to find new markers that can help expedite the evaluation and treatment of MI patients. The current study examines the utility of the stress hormone cortisol as an initial marker of infarction in patients presenting to the ED with acute chest pain. Objectives To determine if serum cortisol levels are significantly altered in patients presenting with acute chest pain of cardiac etiology. Methods A convenience sample of patients presenting with a chief complaint of chest pain were enrolled. All patients had blood drawn for cortisol levels in addition to standard cardiac enzymes. Patient charts were reviewed after ED or hospital discharge to obtain data on EKG changes, initial and maximum troponin levels and final diagnosis. Results 113 patients were enrolled. 35 had elevated serum cortisol levels (>18 ug/dl) with levels being higher in those patients with chest pain of cardiac etiology than in non-cardiac cases (17.1 ? 1.9 vs. 12.3 ? 1.0; p Conclusions Cortisol levels were found to be high in patients with cardiac chest pain, and significantly elevated in patients diagnosed with MI. This suggests that cortisol may be a valuable predictor of cardiac disease and could potentially serve as a cardiac marker for MI in the emergency setting. Link to comment Share on other sites More sharing options...
This topic is now archived and is closed to further replies.