Chief Cushie ~MaryO~ Posted July 16, 2007 Chief Cushie Report Share Posted July 16, 2007 http://www.sciencedirect.com/science?_ob=A...0aab49e2071b12d Both slow-release and regular-form metformin improve glycemic control without altering plasma visfatin level in patients with type 2 diabetes mellitus Chang-Hsun Hsieha, Chih-Tseung Hea, Chien-Hsing Leea, Ling-Yi Wua and Yi-Jen HungCorresponding Author Contact Information, a, E-mail The Corresponding Author aDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC Received 19 December 2006; accepted 20 March 2007. Available online 6 July 2007. Abstract Both slow-release (SR) and regular-release (RR) metformin were effective in the treatment of type 2 diabetes mellitus. We compare the efficacy, safety, and effects on serum adipocytokines and inflammatory markers of both regimens in patients with type 2 diabetes mellitus. A prospective, randomized, double-blind study enrolled 55 patients with type 2 diabetes mellitus, which were randomly assigned to receive either metformin SR or RR (at a maximal dosage of 2000 mg/d for 12 weeks). Glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose, adipocytokines, C-reactive protein, and insulin resistance and pancreatic beta-cell function were measured before and after treatment. Significant decreases (P Corresponding Author Contact InformationCorresponding author. Tel.: +886 2 87927182; fax: +886 287927183. Metabolism Volume 56, Issue 8, August 2007, Pages 1087-1092 Link to comment Share on other sites More sharing options...
This topic is now archived and is closed to further replies.