Chief Cushie ~MaryO~ Posted August 7, 2007 Chief Cushie Report Share Posted August 7, 2007 http://jcem.endojournals.org/cgi/content/abstract/92/8/2965 Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0181 The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 8 2965-2971 Copyright ? 2007 by The Endocrine Society Measurement of Salivary Cortisol Concentration in the Assessment of Adrenal Function in Critically Ill Subjects: A Surrogate Marker of the Circulating Free Cortisol Baha M. Arafah, Fumie J. Nishiyama, Haytham Tlaygeh and Rana Hejal Divisions of Clinical and Molecular Endocrinology (B.M.A., F.J.N.) and Pulmonary and Critical Care Medicine (H.T., R.H.), University Hospitals/Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106 Address all correspondence and requests for reprints to: Baha M. Arafah, M.D., Division of Clinical and Molecular Endocrinology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106. E-mail: firstname.lastname@example.org. Methods: Baseline and cosyntropin-stimulated serum (total and free) and salivary cortisol concentrations were measured, in the early afternoon, in 51 critically ill patients and healthy subjects. Patients were stratified according to their serum albumin at the time of testing: those whose serum albumin levels were 2.5 gm/dl or less vs. others whose levels were greater than 2.5 gm/dl. Results: Baseline and cosyntropin-stimulated serum free cortisol levels were similar in the two groups of critically ill patients and were severalfold higher (P Conclusions: Salivary cortisol measurements are simple to obtain, easy to measure in most laboratories, and provide an indirect yet reliable and practical assessment of the serum free cortisol concentrations during critical illnesses. The concentrations of the two measures of unbound cortisol determined in two different body fluids correlated very well, regardless of the serum protein concentrations. Measurements of salivary cortisol can serve as a surrogate marker for the free cortisol in the circulation. Link to comment Share on other sites More sharing options...
This topic is now archived and is closed to further replies.