staticnrg Posted November 3, 2007 Report Share Posted November 3, 2007 Stress Response in Older Adults Linked to Birth Weight Inviato da Cybermed sabato 03 novembre 2007 There appears to be an inverse U-shaped association between birth weight and cortisol concentrations during psychosocial stress in late adulthood, according to study results published in the November issue of the Journal of Clinical Endocrinology and Metabolism, published early online. "During the past decade it has become increasingly clear that circumstances during the fetal period may have a substantial impact on susceptibility to several common adult disorders such as cardiovascular disease and depression," write Dr. Eero Kajantie, of the National Public Health Institute, Helsinki, Finland, and colleagues. "Life-long programming of the hypothalamic-pituitary-adrenal axis (HPAA) is a key candidate in mediating this link." The researchers examined whether body size at birth is associated with HPAA response to psychosocial stress in late adulthood in 287 men and women in the Helsinki Birth Cohort who were born between 1934 and 1944. Salivary cortisol was measured in conjunction with a standardized psychosocial stressor (Trier Social Stress Test). Plasma cortisol and adrenocorticotropin hormone (ACTH) concentrations were also measured in 215 subjects. A linear relationship was observed between birth weight and plasma ACTH, whereas there were quadratic relationships between birth weight and salivary and plasma cortisol. Peak salivary cortisol concentrations were 12.9 nmol/L in the lowest tertile of birth weight compared with 17.1 nmol/L in the middle and 14.1 nmol/L in the highest. Corresponding figures for plasma cortisol were 418 nmol/L, 498 nmol/L, and 454 nmol/L, respectively. "These results reinforce previous suggestions that both hyper- and hypocortisolism may be programmed during the fetal period and prompt further studies on early life origins of hypocortisolism and associated disorders," Dr. Kajantie and colleagues conclude. The researchers note that there's evidence that "people born at term with low birth weight may be more likely to experience psychosocial stress in middle-age." They point out that hypocortisolism is a feature of disorders such as posttraumatic stress disorder, fibromyalgia, and chronic fatigue syndrome. J Clin Endocrinol Metab 2007 PDF (click me)I find this interesting because I was a low-birth-weight baby. So was my older daughter. Hugs,Robin Link to comment Share on other sites More sharing options...
MCF Posted November 3, 2007 Report Share Posted November 3, 2007 We were all normal, average sized babies in my family, yet we definitely have some sort of multi generation HPA wierdness going on. Out of step, as usual. Susan, with a red swollen face, worsening sinus infection after weeks of abx, and another 2.4 midnight serum cortisol. Link to comment Share on other sites More sharing options...
Over 2000 Posts casag Posted November 3, 2007 Over 2000 Posts Report Share Posted November 3, 2007 Yep -- just a little over 5 pounds. Link to comment Share on other sites More sharing options...
Over 2000 Posts JenS Posted November 3, 2007 Over 2000 Posts Report Share Posted November 3, 2007 6lbs 4oz. What the heck happened! Link to comment Share on other sites More sharing options...
Member of the 1000 Post Club Llama3234 Posted November 3, 2007 Member of the 1000 Post Club Report Share Posted November 3, 2007 I was 7*11. And Justin was about 4-5 pounds, but he was a premie(1 month early), so I guess if he woulda been born when he was supposed to, he probably woulda been a bit bigger. -Jessie* Link to comment Share on other sites More sharing options...
hollyfm Posted November 4, 2007 Report Share Posted November 4, 2007 Very interesting, Devin was 4lbs. 8 oz. Link to comment Share on other sites More sharing options...
mertie Posted November 4, 2007 Report Share Posted November 4, 2007 I was normal weight, but my sister was 5 pounds and she has some suspected pit problems. Interesting! Link to comment Share on other sites More sharing options...
judycolby Posted November 4, 2007 Report Share Posted November 4, 2007 On a little different note, but relating to pregnancy, if the kids were born with this and something was developing abnormally in the womb, could that be the cause of me being sick with both kids. Kept down absolutely nothing with Justin. With Jess I kept down more because I took B12 (B6? shots) but was still nauseous all the time. I had never thought of this before. And probably I was just one of those that pregnancy didn't agree with. But it does make you wonder Judy Link to comment Share on other sites More sharing options...
gretchenR Posted November 4, 2007 Report Share Posted November 4, 2007 I was 6 lb 7oz. My Mom had thyroid issues when she was pregnant with me ... hummmm Link to comment Share on other sites More sharing options...
Over 2000 Posts Judy from Pgh Posted November 4, 2007 Over 2000 Posts Report Share Posted November 4, 2007 .i dont know the weight, but i was told i was a very small baby. ...my mother always told me she was in labor three days with me and then after delivery she had pneumonia and fever and she had to be packed in ice !!! ..somehow my birth weight got lost in the drama of the delivery...... ........................ my first son jon was 7lb 14oz .......thyroid problems my second son jay was 9lbs..........no known pit/thyroid problems Link to comment Share on other sites More sharing options...
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