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Advances in the Management of Paediatric Cushing's Disease

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Advances in the Management of Paediatric Cushing's Disease


Martin O. Savage, Li F. Chan, Farhad Afshar, P. Nicholas Plowman, Ashley B. Grossman, Helen L. Storr


Departments of Endocrinology, Neurosurgery and Radiotherapy, Barts and the London School of Medicine and Dentistry, London, UK


Address of Corresponding Author


Horm Res 2008;69:327-333 (DOI: 10.1159/000117388)


Key Words


* Cushing's disease

* Paediatrics

* Transsphenoidal surgery

* Pituitary radiotherapy




Cushing's disease (CD) is rare in the paediatric age range, but may present a difficult therapeutic challenge. Most paediatric endocrinologists have limited experience managing children or adolescents with CD and thus benefit from close consultation with adult colleagues. Prior to definitive treatment, a diagnostic protocol for investigation is required which broadly follows the model for adult patients. Treatment strategies for CD are described and critically appraised. The management of paediatric CD patients after cure also presents challenges for optimizing growth, bone health, reproduction and body composition from childhood into and during adult life.


Copyright ? 2008 S. Karger AG, Basel


Author Contacts


Prof. Martin Savage, Department of Endocrinology

Barts and the London School of Medicine and Dentistry

John Vane Science Centre, Charterhouse Square

London EC1M 6BQ (UK)

Tel. +44 20 7882 6233, Fax +44 7882 6234, E-Mail m.o.savage@qmul.ac.uk


Article Information


Received: March 5, 2007

Accepted: October 2, 2007

Published online: March 17, 2008

Number of Print Pages : 7

Number of Figures : 3, Number of Tables : 3, Number of References : 49



Free Abstract Article (Fulltext) Article (PDF 230 KB)

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