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Insulin Resistence

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Here is an in-depth paper about type II diabetes. I'm not kidding either...this stuff is real scienific receptors stuff that is way over the heads kind of discussion for most of us. It is interesting though. What I got out of it was that the drugs are designed to try to balance out the system so that the 'plugs' plug into the 'receptacles' tee hee "the yellow ones go here and the orange ones go here"...ha ha...just joking...for real though...if you are into deep thoughts about diabetes...this is pretty deep and probably more that what most of us mousekateers think about at 2 a.m. The burning question I always hear is "Why does glucophage upset my stomach!"

Here is the link:



is the summary:

Pathophysiology and Pharmacological Treatment of Insulin Resistance1

Stephan Matthaei, Michael Stumvoll, Monika Kellerer and Hans-Ulrich H?ring

Department of Internal Medicine IV (Endocrinology, Metabolism, Angiology, Pathobiochemistry and Clinical Chemistry), University of T?bingen, D-72076 T?bingen, Germany

Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150 million people at the beginning of the new millennium. It is believed that this number will double in the next 25 yr. The pathophysiological hallmarks of type 2 diabetes mellitus consist of insulin resistance, pancreatic ?-cell dysfunction, and increased endogenous glucose production. To reduce the marked increase of cardiovascular mortality of type 2 diabetic subjects, optimal treatment aims at normalization of body weight, glycemia, blood pressure, and lipidemia. This review focuses on the pathophysiology and molecular pathogenesis of insulin resistance and on the capability of antihyperglycemic pharmacological agents to treat insulin resistance, i.e., -glucosidase inhibitors, biguanides, thiazolidinediones, sulfonylureas, and insulin. Finally, a rational treatment approach is proposed based on the dynamic pathophysiological abnormalities of this highly heterogeneous and progressive disease.

(Yeah - glucophage that upsets the stomach! yuk yuk)


(Edited by Kristy at 10:24 pm on Jan. 3, 2002)

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