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UCLA And Biotech Company Develop First Blood Test To Measure Key Hormone That Regulates Iron

Main Category: Endocrinology

Also Included In: Blood / Hematology

Article Date: 10 Aug 2008 - 1:00 PDT


UCLA and Intrinsic LifeSciences, a San Diego biotech company, developed the first method to measure the hormone, hepcidin, which regulates the absorption of dietary iron and its distribution in the body. This new blood test will help clinicians manage chronic conditions affecting millions of people worldwide such as anemias and iron overload diseases.


The new test will measure the amount of hepcidin in the blood. When levels of the hormone are too high, the availability of iron is blocked, leading to conditions like anemia of chronic disease. When levels are low, too much iron is absorbed from the diet and released into the blood, leading to iron toxicity and conditions like hemochromatosis or iron overload disease. The current tests do not measure hepcidin but instead measure some of its direct and indirect effects on iron and the iron-binding proteins transferrin and ferritin. The new blood test will directly measure hepcidin, offering more information to clinicians to help diagnose conditions and monitor the levels of this important hormone in their patients -- leading to more efficient management of these chronic diseases.


Funded by Intrinsic LifeSciences, LLC.



Dr. Tomas Ganz, professor of medicine at the David Geffen School of Medicine at UCLA and Mark Westerman, Ph.D., chief executive officer of Intrinsic LifeSciences, LLC, are available for interviews. Dr. Ganz is also a co-founder of the company.


The research appears in the Aug. 8 online edition of the peer-reviewed journal Blood



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I have had trouble bringing my ferriten up too. Even on Iron it dropped. I will be coureous to see if it goes up now that I am not bleeding everyday due to my TAH. Robin thanks for this info. Maybe if my ferriten does not go up they can test this hormone.




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I've been needing this answer for a long time. I'm taking 15 of those Iron Sorb capsules for over 6 months and still have my ferritin drop drastically.


I guess now all we need to know is how we can raise or lower our hepcidin levels!!!!


When somethings wrong and you can't figure it out.......there's usually a hormone to blame! :)


Thanks ROBIN!!!

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I did get the full article and send it on to Dr. F, plus I found more. I've just updated my delicious site(Click me) with more info, and the new ones are listed below. The hepcidin articles are included. Remember, you can make your own delicious site and bookmark anything I have on mine that you want to keep for you. It's a great tool, and makes it easy to find info. I keep this updated FOR ALL OF YOU so that you can research and look up things ANYTIME. Use the "tags" to find information. The link to it is always in my signature.


Hugs and love!






































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