Chief Cushie ~MaryO~ Posted September 19, 2008 Chief Cushie Report Share Posted September 19, 2008 Vascular Health and Risk Management Issue: Issue 4 Cardiovascular consequences of cortisol excess Judith A Whitworth1, Paula M Williamson1, George Mangos2, John J Kelly2 1John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia; 2Department of Renal Medicine, St George Hospital, Kogarah, NSW, Australia Abstract: Cushing?s syndrome is a consequence of primary or, more commonly, secondary oversecretion of cortisol. Cardiovascular disease is the major cause of morbidity and mortality in Cushing?s syndrome, and excess risk remains even in effectively treated patients. The cardiovascular consequences of cortisol excess are protean and include, inter alia, elevation of blood pressure, truncal obesity, hyperinsulinemia, hyperglycemia, insulin resistance, and dyslipidemia. This review analyses the relationship of cortisol excess, both locally and at tissue level, to these cardiovascular risk factors, and to putative mechanisms for hypertension. Previous studies have examined correlations between cortisol, blood pressure, and other parameters in the general population and in Cushing?s syndrome. This review also details changes induced by short-term cortisol administration in normotensive healthy men. Keywords: blood pressure, cortisol, Cushing?s syndrome, risk factors Purchase this paper now Price: $59 USD Link to comment Share on other sites More sharing options...
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