Chief Cushie ~MaryO~ Posted October 10, 2008 Chief Cushie Report Share Posted October 10, 2008 from this long URL Subclinical Cushing's syndrome is a potential cause of metabolic dementia and rapidly progressive Alzheimer-type dementia Sibel Guldikena, , and Baburhan Guldikenb aDepartment of Endocrinology, Trakya University, Medical Faculty, Edirne 22030, Turkey bDepartment of Neurology, Trakya University, Medical Faculty, Edirne, Turkey Received 29 May 2008; accepted 30 May 2008. Available online 17 September 2008. References and further reading may be available for this article. To view references and further reading you must purchase this article. Summary Excess of glucocorticoid hormones are found to exert deleterious effects on the structure and function of central nervous system, especially the hippocampus. This is manifested as mental and mood changes in Cushing syndrome. Subclinical Cushing's syndrome (SCS) is much more prevalent than Cushing's syndrome, and presents with increased plasma cortisol levels, but lack of the cardinal manifestations of Cushing's syndrome. In dementia, the impairment of hypothalamic?pituitary?adrenal axis has been shown, and hypercortisolism has been accused for rapidly progressive cognitive decline in Alzheimer disease. We hypothesized that SCS may cause metabolic dementia, and should be searched in case of rapidly progressive dementia of Alzheimer type. Article Outline Introduction Hypothesis Discussion References Link to comment Share on other sites More sharing options...
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