The difficulties of Cushing?s syndrome

[ADDflower]

http://www.endocrinetoday.com/view.aspx?rid=33057

 

The difficulties of Cushing?s syndrome

Diagnosing and treating Cushing?s syndrome is sometimes just as difficult as it was 70 years ago.

 

For as long as it has been described, Cushing?s syndrome has presented physicians with a problem. Harvey Cushing first described it in 1932, and the diagnosis, differential diagnosis and treatment of Cushing?s have remained a major challenge for endocrinologists ever since.

 

Though uncommon, it is difficult to consider Cushing?s syndrome a rare occurrence. New research has shown Cushing?s syndrome to have a substantially higher prevalence than previously thought. Unexpected endogenous hypercortisolism may occur in 0.5% to 1% of patients with hypertension, 2% to 3% with poorly controlled diabetes, 6% to 9% with incidental adrenal masses and 11% with osteoporosis and vertebral fractures.

 

?We are gaining an appreciation that Cushing?s is more common than it was once believed to be,? said Mary Ruppe, MD, endocrinologist at the University of Texas Health Science Center at Houston, and program committee chair of the Women in Endocrinology organization. ?This fact points to the need for data regarding the value of the different diagnostic approaches and for data regarding treatment/outcomes in populations with Cushing?s.?

 

As most of the characteristics of Cushing?s are common in the general population, including obesity, depression and hypertension, it is extremely difficult for endocrinologists to decide on who should be screened for the disorder. A recent clinical review by Hershel Raff, PhD, and James W. Findling, MD, noted that as the number of patients in these high-risk groups continues to increase, the need for a sensitive and specific diagnostic test for Cushing?s syndrome has become paramount.

 

The three most commonly performed diagnostic studies for Cushing?s syndrome ? urine-free cortisol, low-dose dexamethasone suppression test and the nocturnal salivary cortisol ? are also not without hurdles. All three have been shown to produce false positives and false negatives.

 

 

 

Approximately 80% of patients with Cushing?s syndrome have an adrenocorticotropic-secreting neoplasm from a pituitary tumor (Cushing?s disease) or a nonpituitary neoplasm, and the treatment of Cushing?s disease remains challenging for both endocrinologists and neurosurgeons as well. Transsphenoidal surgery is currently the standard treatment of choice in patients, but achieving surgical remission has been difficult as well.

 

?Cushing?s syndrome is a very rare but important diagnosis for the patient and endocrinologist. Confirming the diagnosis may be challenging, and before embarking on a costly set of tests, the endocrinologist should be reasonably assured that the patient indeed requires diagnostic exclusion by rigorous screening methods,? said Shlomo Melmed, MD, senior vice president of Academic Affairs at Cedars Sinai Medical Center, Los Angeles, and an Endocrine Today editorial board member.

 

With more than 7.5 decades of research since Dr. Cushing?s discovery, what are the best methods of diagnosis and treatment for Cushing?s syndrome? Endocrine Today talked with leading researchers in the field to uncover the current trends in Cushing?s syndrome treatment.

 

Screening process

 

Laurence Katznelson, MD, associate professor of medicine and neurosurgery at Stanford University, and medical director of the pituitary program at Stanford Hospital and Clinics, explained to Endocrine Today the difficulty of deciding who should be screened for Cushing?s syndrome. For instance, although the syndrome is associated with multiple comorbidities, including obesity, hypertension and depression, endocrinologists should be prepared to delve a little deeper into the symptoms to see if they warrant a screening test.

 

?The presence of Cushing?s syndrome should be considered if these medical conditions are present, though diagnostic testing should be performed only in subjects who have signs favoring Cushing?s, such as demonstration of objective proximal weakness, spontaneous ecchymoses and violaceous striae,? Katznelson said.

 

?For example, central obesity with supraclavicular and dorsicervical fat pads would favor a diagnosis of Cushing?s syndrome, in contrast to the presence of generalized obesity,? he said.

 

Raff and Findling noted in a recent clinical review that endogenous cortisol excess also leads to fairly specific catabolic effects ? including the thinning of the skin with easy bruising, abdominal striae, poor wound healing, immune suppression, rib fractures, hirsutism in women, acne and muscle wasting leading to proximal muscle weakness.

 

?There is no clear guideline,? said Roberto Salvatori, MD, associate professor of medicine in the division of endocrinology at Johns Hopkins University School of Medicine. ?You need to keep your mind open.?

 

?Sometimes Cushing?s is obvious. Sometimes, when it is mild, it may not be diagnosed for many years. One must screen a lot of patients to find one with Cushing?s. However, anytime a physician thinks about the possibility of a patient having the disease, work-up should be initiated,? he said.

 

Testing options

 

Opinions varied when Endocrine Today asked researchers which of the three tests for Cushing?s syndrome was most reliable.

 

?No test is 100% sensitive or specific,? Salvatori said. ?I always use two, sometimes three, screening tests.? However, Salvatori noted he feels the night-time salivary cortisol test is the most reliable and easy to obtain.

 

Raff and Findling described the measurement of free cortisol in a 24-hour urine collection as being long considered the gold standard for the diagnosis of endogenous hypercortisolism. The test relies on the concept that as daily production of cortisol is increased, the free cortisol filtered and not reabsorbed or metabolized in the kidneys will be increased. They noted that current research has shown that many patients with mild Cushing?s syndrome do not have elevations of urine-free cortisol, ?making it a poor screening test for this condition.?

 

The low-dose dexamethasone suppression test relies on the concept that the correct dose of dexamethasone will suppress ACTH, and cortisol will release in normal patients while patients with corticotroph adenomas will not suppress below a specified cut off. Raff and Findling noted that because of the significant variability of the biological behavior of corticotroph adenomas, research has shown that neither the overnight 1-mg dexamethasone suppression test nor the two-day low-dose dexamethasone suppression test appears to be reliable using the standard cutoffs for serum cortisol.

 

According to Raff and Findling, there is no diagnostic test used in the evaluation of Cushing?s syndrome that performs better than the late night/midnight salivary cortisol method. The concept is based on the fact that patients with mild Cushing?s syndrome fail to decrease cortisol secretion to its nadir at night. However, they still acknowledged that many factors, such as stress, sleep disturbances and psycho-neuroendocrine may falsely elevate nocturnal cortisol secretion.

 

?Because each of these tests has associated false positives and negatives, a combination of these tests is often necessary for a valid diagnosis,? Katznelson said. ?In the end, these tests need to be considered in the context of a history and physical examination that favors this diagnosis.?

 

Lynette Nieman, MD, associate director of the Intramural Endocrinology Training Program at the NIH, agreed. ?Of the three recommended tests, each is useful in certain conditions,? she said. ?I try to stress that the testing should be individualized since some tests are likely to be falsely positive in some situations, eg, a woman on birth control pills is likely to have a high corticosteriod-binding globulin, which might elevate serum cortisol.?

 

Ruppe said the choice between the tests should be based on patient characteristics that will allow for adequate collection of each sample. ?For instance, the use of a late-night salivary cortisol measurement would be suboptimal in an individual who works the third shift and may not have an intact circadian rhythm, or the choice of a 24-hour urinary free cortisol may be suboptimal in an individual with urinary frequency or urinary incontinence.?

 

Ruppe also noted that one possible improvement would be to improve standardization of the assays across different labs. ?Since there is no standardization, the quality of the performance of the assay can vary across different facilities and centers,? she said.

 

Petrosol sinus sampling

 

Another controversial topic in the field is whether or not the inferior petrosol sinus should be sampled for an ACTH gradient to distinguish between Cushing?s disease and occult ectopic ACTH syndrome.

 

The invasive procedure has proven to be relatively safe when performed by experienced radiologists, but not all medical centers have the capability.

 

A woman with mild hypercortisolism, a normal or slightly elevated plasma ACTH and normokalemia has an approximately 95% likelihood of having Cushing?s disease before any differential diagnostic testing is performed, according to Raff and Findling. In contrast, a male patient with prodigious hypercortisolism of rapid onset, hypokalemia and marked elevations of plasma ACTH may be more likely to have an occult ectopic ACTH-secreting tumor.

 

About half of patients with ACTH-secreting microadenomas are estimated to have a normal pituitary MRI. In such situations, it is important to perform further testing, particularly an inferior petrosal sinus catheterization, to discern the presence of an ectopic ACTH-producing lesion, according to Katznelson.

 

?Some people would say that every patient should have it because it is the one best test for the differential diagnosis of ACTH-dependent Cushing?s syndrome,? Nieman said. ?However, patients in whom data strongly suggest Cushing?s disease might forego it.?

 

?In a young woman with an MRI with a definitive adenoma and high-dose dexamethasone test showing less than 60% suppression, it is reasonable to proceed with surgery,? Salvatori said. ?But even the International Prostate Symptom Score is not 100% sensitive or specific.? Raff said that he disagrees with the high-dose dexamethasone test.

 

Transsphenoidal surgery

 

Currently, transsphenoidal surgery is the primary treatment of Cushing?s disease associated with an ACTH-secreting pituitary tumor. According to recent studies, remission rates after transsphenoidal pituitary microsurgery range from 42% to 86%.

 

Raff told Endocrine Today that the most important treatment recommendation that an endocrinologist makes to a patient with Cushing?s disease is referral to a neurosurgeon with extensive experience.

 

?Referral to a neurosurgeon who is highly experienced in this procedure is critical,? Katznelson agreed. He noted that there have been studies demonstrating that both the degree of tumor bulk resection and rates of biochemical remission are increased for all types of pituitary tumors when the surgery is performed by a neurosurgeon with extensive experience in endonasal pituitary surgery.

 

?In Cushing?s disease, this is especially true,? Katznelson said. ?Because the tumors in this disorder are often small, if not microscopic, the surgical strategy may require dissection through the gland. In inexperienced hands, this may result in higher rates of hypopituitarism and lower rates of biochemical cure,? Katznelson said.

 

?There is no doubt that the surgeon?s experience influences the success rate,? Nieman said.

 

Constantine Stratakis, MD, with the National Institute of Child Health and Human Development, said he agreed, and stressed the importance of confirmation of diagnosis of Cushing?s syndrome prior to a referral to a neurosurgeon.

 

?There is nothing worse than an inexperienced surgeon operating on a patient with Cushing?s or a surgeon operating on a patient who does not have a firm diagnosis of Cushing?s syndrome,? Stratakis said.

 

?Surgery offers a reasonable chance for cure in the hands of an experienced neurosurgeon,? said Amir Hamrahian, MD, a staff physician at the Endocrinology Institute at the Cleveland Clinic. ?We are currently involved in two studies looking at new medications for medical treatment of patients with Cushing?s syndrome. However, surgery is still the best initial approach for those not cured,? Hamrahian said.

 

The future

 

?Medications are the future for patients with inoperable, recurrent Cushing?s syndrome,? Stratakis said, referring to pasireotide (SOM230), a somatostatin analog.

 

He was part of a study in 2006 examining the in vitro effects of SOM230 on cell proliferation in human corticotroph tumors. Researchers found SOM230 significantly suppressed cell proliferation and ACTH secretion in primary cultures of human corticotroph tumors. They concluded that SOM230 may have a role in the medical therapy of Cushing?s disease. Raff said he believes that clinical trials in patients with Cushing?s disease who used SOM230 were not particularly successful. Anne Klibanski, MD, director of the neuroendocrine clinical center at Massachusetts General Hospital and primary investigator of the study, commented that in vitro studies play a critical role in assessing novel targeted pituitary tumor therapies. It is only in rigorous clinical trials that the overall efficacy and risks of such therapies can be established, she suggested.

 

?Microsurgical improvements will also be significant, but the major problem right now is the number of patients who are left untreated with recurrent disease,? Stratakis said. ?For them, there are very few options other than irradiation, so innovative medical treatments with molecularly designed compounds or targeted to specific receptors and/or functions of the pituitary are the most important advances that I see coming in the near future,? Stratakis said.

 

According to James Liu, MD, assistant professor of neurologic surgery at Northwestern University Feinberg School of Medicine in Evanston, Ill., the future appears bright in the battle against Cushing?s.

 

?Technical advances in surgery including endoscopic pituitary surgery and pseudocapsular dissection can improve surgical outcomes,? Liu said.

 

Katznelson said he hopes the future will bring improved diagnostic strategies important for detecting true Cushing?s syndrome in the presence of multiple comorbidities. He noted that the ongoing research studies involving innovative medical therapeutic strategies that target the corticotroph adenoma itself, or block the effects of cortisol in the periphery, should bring new treatment options in the future.

 

?These studies will hopefully lead to novel medical options for this syndrome,? Katznelson said. ?There have been significant advances in surgery, particularly with the development of minimally invasive, endoscopic surgery that has resulted in both improved biochemical outcomes and patient tolerability.? ? by Angelo Milone

[JenS]

Thanks Ami...

At least some of them seem to think it may not be so rare - maybe they should google and find us!

[sowens]

Raff and Findling are making major headway with Cushing's. My endo most go and listen to them speak. I know she has been talking about them a lot the past few months.

 

Raff signed off on my IPSS testing. My endo likes Findling because he believes totally in Cushing's like ours is...non-text book. Findling was a fall back just in case we didn't find a surgeon for my adrenal case. At least one of those others doesn't have such a good name when it comes to Cushing's. It is good to see there are more options available than just the West Coast on the horizon.

[~MaryO~]

from http://www.endocrinetoday.com/view.aspx?rid=33057

 

The difficulties of Cushing?s syndrome

 

Diagnosing and treating Cushing?s syndrome is sometimes just as difficult as it was 70 years ago.

 

For as long as it has been described, Cushing?s syndrome has presented physicians with a problem. Harvey Cushing first described it in 1932, and the diagnosis, differential diagnosis and treatment of Cushing?s have remained a major challenge for endocrinologists ever since.

 

Though uncommon, it is difficult to consider Cushing?s syndrome a rare occurrence. New research has shown Cushing?s syndrome to have a substantially higher prevalence than previously thought. Unexpected endogenous hypercortisolism may occur in 0.5% to 1% of patients with hypertension, 2% to 3% with poorly controlled diabetes, 6% to 9% with incidental adrenal masses and 11% with osteoporosis and vertebral fractures.

 

?We are gaining an appreciation that Cushing?s is more common than it was once believed to be,? said Mary Ruppe, MD, endocrinologist at the University of Texas Health Science Center at Houston, and program committee chair of the Women in Endocrinology organization. ?This fact points to the need for data regarding the value of the different diagnostic approaches and for data regarding treatment/outcomes in populations with Cushing?s.?

 

As most of the characteristics of Cushing?s are common in the general population, including obesity, depression and hypertension, it is extremely difficult for endocrinologists to decide on who should be screened for the disorder. A recent clinical review by Hershel Raff, PhD, and James W. Findling, MD, noted that as the number of patients in these high-risk groups continues to increase, the need for a sensitive and specific diagnostic test for Cushing?s syndrome has become paramount.

 

How do you diagnose Cushing's syndrome?

 

The three most commonly performed diagnostic studies for Cushing?s syndrome ? urine-free cortisol, low-dose dexamethasone suppression test and the nocturnal salivary cortisol ? are also not without hurdles. All three have been shown to produce false positives and false negatives.

 

Shlomo Melmed

 

Approximately 80% of patients with Cushing?s syndrome have an adrenocorticotropic-secreting neoplasm from a pituitary tumor (Cushing?s disease) or a nonpituitary neoplasm, and the treatment of Cushing?s disease remains challenging for both endocrinologists and neurosurgeons as well. Transsphenoidal surgery is currently the standard treatment of choice in patients, but achieving surgical remission has been difficult as well.

 

?Cushing?s syndrome is a very rare but important diagnosis for the patient and endocrinologist. Confirming the diagnosis may be challenging, and before embarking on a costly set of tests, the endocrinologist should be reasonably assured that the patient indeed requires diagnostic exclusion by rigorous screening methods,? said Shlomo Melmed, MD, senior vice president of Academic Affairs at Cedars Sinai Medical Center, Los Angeles, and an Endocrine Today editorial board member.

 

With more than 7.5 decades of research since Dr. Cushing?s discovery, what are the best methods of diagnosis and treatment for Cushing?s syndrome? Endocrine Today talked with leading researchers in the field to uncover the current trends in Cushing?s syndrome treatment.

 

Screening process

 

Laurence Katznelson, MD, is Associate Professor of Medicine and Neurosurgery at Stanford University, and Medical Director of the Pituitary Program at Stanford Hospital and Clinics.

 

Photo by Norbert Von der Groeben

 

 

 

 

 

Laurence Katznelson, MD, associate professor of medicine and neurosurgery at Stanford University, and medical director of the pituitary program at Stanford Hospital and Clinics, explained to Endocrine Today the difficulty of deciding who should be screened for Cushing?s syndrome. For instance, although the syndrome is associated with multiple comorbidities, including obesity, hypertension and depression, endocrinologists should be prepared to delve a little deeper into the symptoms to see if they warrant a screening test.

 

?The presence of Cushing?s syndrome should be considered if these medical conditions are present, though diagnostic testing should be performed only in subjects who have signs favoring Cushing?s, such as demonstration of objective proximal weakness, spontaneous ecchymoses and violaceous striae,? Katznelson said.

 

?For example, central obesity with supraclavicular and dorsicervical fat pads would favor a diagnosis of Cushing?s syndrome, in contrast to the presence of generalized obesity,? he said.

 

Raff and Findling noted in a recent clinical review that endogenous cortisol excess also leads to fairly specific catabolic effects ? including the thinning of the skin with easy bruising, abdominal striae, poor wound healing, immune suppression, rib fractures, hirsutism in women, acne and muscle wasting leading to proximal muscle weakness.

 

?There is no clear guideline,? said Roberto Salvatori, MD, associate professor of medicine in the division of endocrinology at Johns Hopkins University School of Medicine. ?You need to keep your mind open.?

 

?Sometimes Cushing?s is obvious. Sometimes, when it is mild, it may not be diagnosed for many years. One must screen a lot of patients to find one with Cushing?s. However, anytime a physician thinks about the possibility of a patient having the disease, work-up should be initiated,? he said.

 

Testing options

 

Opinions varied when Endocrine Today asked researchers which of the three tests for Cushing?s syndrome was most reliable.

 

?No test is 100% sensitive or specific,? Salvatori said. ?I always use two, sometimes three, screening tests.? However, Salvatori noted he feels the night-time salivary cortisol test is the most reliable and easy to obtain.

 

Raff and Findling described the measurement of free cortisol in a 24-hour urine collection as being long considered the gold standard for the diagnosis of endogenous hypercortisolism. The test relies on the concept that as daily production of cortisol is increased, the free cortisol filtered and not reabsorbed or metabolized in the kidneys will be increased. They noted that current research has shown that many patients with mild Cushing?s syndrome do not have elevations of urine-free cortisol, ?making it a poor screening test for this condition.?

 

The low-dose dexamethasone suppression test relies on the concept that the correct dose of dexamethasone will suppress ACTH, and cortisol will release in normal patients while patients with corticotroph adenomas will not suppress below a specified cut off. Raff and Findling noted that because of the significant variability of the biological behavior of corticotroph adenomas, research has shown that neither the overnight 1-mg dexamethasone suppression test nor the two-day low-dose dexamethasone suppression test appears to be reliable using the standard cutoffs for serum cortisol.

 

According to Raff and Findling, there is no diagnostic test used in the evaluation of Cushing?s syndrome that performs better than the late night/midnight salivary cortisol method. The concept is based on the fact that patients with mild Cushing?s syndrome fail to decrease cortisol secretion to its nadir at night. However, they still acknowledged that many factors, such as stress, sleep disturbances and psycho-neuroendocrine may falsely elevate nocturnal cortisol secretion.

 

?Because each of these tests has associated false positives and negatives, a combination of these tests is often necessary for a valid diagnosis,? Katznelson said. ?In the end, these tests need to be considered in the context of a history and physical examination that favors this diagnosis.?

 

Lynette Nieman, MD, associate director of the Intramural Endocrinology Training Program at the NIH, agreed. ?Of the three recommended tests, each is useful in certain conditions,? she said. ?I try to stress that the testing should be individualized since some tests are likely to be falsely positive in some situations, eg, a woman on birth control pills is likely to have a high corticosteriod-binding globulin, which might elevate serum cortisol.?

 

Ruppe said the choice between the tests should be based on patient characteristics that will allow for adequate collection of each sample. ?For instance, the use of a late-night salivary cortisol measurement would be suboptimal in an individual who works the third shift and may not have an intact circadian rhythm, or the choice of a 24-hour urinary free cortisol may be suboptimal in an individual with urinary frequency or urinary incontinence.?

 

Ruppe also noted that one possible improvement would be to improve standardization of the assays across different labs. ?Since there is no standardization, the quality of the performance of the assay can vary across different facilities and centers,? she said.

 

Petrosol sinus sampling

 

Another controversial topic in the field is whether or not the inferior petrosol sinus should be sampled for an ACTH gradient to distinguish between Cushing?s disease and occult ectopic ACTH syndrome.

 

The invasive procedure has proven to be relatively safe when performed by experienced radiologists, but not all medical centers have the capability.

 

A woman with mild hypercortisolism, a normal or slightly elevated plasma ACTH and normokalemia has an approximately 95% likelihood of having Cushing?s disease before any differential diagnostic testing is performed, according to Raff and Findling. In contrast, a male patient with prodigious hypercortisolism of rapid onset, hypokalemia and marked elevations of plasma ACTH may be more likely to have an occult ectopic ACTH-secreting tumor.

 

About half of patients with ACTH-secreting microadenomas are estimated to have a normal pituitary MRI. In such situations, it is important to perform further testing, particularly an inferior petrosal sinus catheterization, to discern the presence of an ectopic ACTH-producing lesion, according to Katznelson.

 

?Some people would say that every patient should have it because it is the one best test for the differential diagnosis of ACTH-dependent Cushing?s syndrome,? Nieman said. ?However, patients in whom data strongly suggest Cushing?s disease might forego it.?

 

?In a young woman with an MRI with a definitive adenoma and high-dose dexamethasone test showing less than 60% suppression, it is reasonable to proceed with surgery,? Salvatori said. ?But even the International Prostate Symptom Score is not 100% sensitive or specific.? Raff said that he disagrees with the high-dose dexamethasone test.

 

 

Transsphenoidal surgery

 

Currently, transsphenoidal surgery is the primary treatment of Cushing?s disease associated with an ACTH-secreting pituitary tumor. According to recent studies, remission rates after transsphenoidal pituitary microsurgery range from 42% to 86%.

 

Raff told Endocrine Today that the most important treatment recommendation that an endocrinologist makes to a patient with Cushing?s disease is referral to a neurosurgeon with extensive experience.

 

?Referral to a neurosurgeon who is highly experienced in this procedure is critical,? Katznelson agreed. He noted that there have been studies demonstrating that both the degree of tumor bulk resection and rates of biochemical remission are increased for all types of pituitary tumors when the surgery is performed by a neurosurgeon with extensive experience in endonasal pituitary surgery.

 

?In Cushing?s disease, this is especially true,? Katznelson said. ?Because the tumors in this disorder are often small, if not microscopic, the surgical strategy may require dissection through the gland. In inexperienced hands, this may result in higher rates of hypopituitarism and lower rates of biochemical cure,? Katznelson said.

 

?There is no doubt that the surgeon?s experience influences the success rate,? Nieman said.

 

Constantine Stratakis, MD, with the National Institute of Child Health and Human Development, said he agreed, and stressed the importance of confirmation of diagnosis of Cushing?s syndrome prior to a referral to a neurosurgeon.

 

?There is nothing worse than an inexperienced surgeon operating on a patient with Cushing?s or a surgeon operating on a patient who does not have a firm diagnosis of Cushing?s syndrome,? Stratakis said.

 

?Surgery offers a reasonable chance for cure in the hands of an experienced neurosurgeon,? said Amir Hamrahian, MD, a staff physician at the Endocrinology Institute at the Cleveland Clinic. ?We are currently involved in two studies looking at new medications for medical treatment of patients with Cushing?s syndrome. However, surgery is still the best initial approach for those not cured,? Hamrahian said.

 

 

 

The future

 

?Medications are the future for patients with inoperable, recurrent Cushing?s syndrome,? Stratakis said, referring to pasireotide (SOM230), a somatostatin analog.

 

He was part of a study in 2006 examining the in vitro effects of SOM230 on cell proliferation in human corticotroph tumors. Researchers found SOM230 significantly suppressed cell proliferation and ACTH secretion in primary cultures of human corticotroph tumors. They concluded that SOM230 may have a role in the medical therapy of Cushing?s disease. Raff said he believes that clinical trials in patients with Cushing?s disease who used SOM230 were not particularly successful. Anne Klibanski, MD, director of the neuroendocrine clinical center at Massachusetts General Hospital and primary investigator of the study, commented that in vitro studies play a critical role in assessing novel targeted pituitary tumor therapies. It is only in rigorous clinical trials that the overall efficacy and risks of such therapies can be established, she suggested.

 

?Microsurgical improvements will also be significant, but the major problem right now is the number of patients who are left untreated with recurrent disease,? Stratakis said. ?For them, there are very few options other than irradiation, so innovative medical treatments with molecularly designed compounds or targeted to specific receptors and/or functions of the pituitary are the most important advances that I see coming in the near future,? Stratakis said.

 

According to James Liu, MD, assistant professor of neurologic surgery at Northwestern University Feinberg School of Medicine in Evanston, Ill., the future appears bright in the battle against Cushing?s.

 

?Technical advances in surgery including endoscopic pituitary surgery and pseudocapsular dissection can improve surgical outcomes,? Liu said.

 

Katznelson said he hopes the future will bring improved diagnostic strategies important for detecting true Cushing?s syndrome in the presence of multiple comorbidities. He noted that the ongoing research studies involving innovative medical therapeutic strategies that target the corticotroph adenoma itself, or block the effects of cortisol in the periphery, should bring new treatment options in the future.

 

?These studies will hopefully lead to novel medical options for this syndrome,? Katznelson said. ?There have been significant advances in surgery, particularly with the development of minimally invasive, endoscopic surgery that has resulted in both improved biochemical outcomes and patient tolerability.? ? by Angelo Milone

 

 

Who should be tested for Cushing's syndrome and what is the best testing method?

 

For more information:

• Aron DC, Raff H, Findling JW. Effectiveness vs. efficacy: the limited value in clinical practice of high-dose dexamethasone suppression testing in the differential diagnosis of ACTH-dependent Cushing?s syndrome. J Clin Endocrinol Metab. 1997:82;1780-1785.
  
  
• Batista DL, Zhang X, Gejman R, et al. The effects of SOM230 on cell proliferation and ACTH secretion in human corticotroph pituitary adenomas. J Clin Endocrinol Metab.2006;91:4482-4488.
  
  
• Carroll T, Raff H, Findling JW. Late-night salivary cortisol measurement in the diagnosis of Cushing?s syndrome. Nat Clin Pract Endocrinol Metab. 2008;4:344-350.
  
  
• Findling JW, Raff H. Cushing?s syndrome: Important issues in diagnosis and management. J Clin Endocrinol Metab. 2006;91:3746-3753
  
  
• Liu JK, Fleseriu M, Delashaw Jr. JB, et al. Treatment options for Cushing?s disease after unsuccessful transsphenoidal surgery. Neurosurg Focus. 2007;23:E8.
  
  
• Nieman L. The dexamethasone-suppresssed corticotropin-releasing hormone test for the diagnosis of Cushing?s syndrome: What have we learned in 14 years? J Clin Endocrinol Metab. 2007;92:2876-2878.
  
  
• Lad SP, Patil CG, Laws ER Jr, Katznelson L. The role of inferior petrosal sinus sampling in the diagnostic localization of Cushing?s disease. Neurosurg Focus. 2007:23:E2.g
  
  

[denney]

Definitely worth the read Mary. It was all good info and interesting that the experts don't always agree on the details. One of my favorite points was the one they made about the inadequacy of the low dose dex test. Hopefully, this gets more and more known among endos and stops preventing patients from being evaluated.

 

The low-dose dexamethasone suppression test relies on the concept that the correct dose of dexamethasone will suppress ACTH, and cortisol will release in normal patients while patients with corticotroph adenomas will not suppress below a specified cut off. Raff and Findling noted that because of the significant variability of the biological behavior of corticotroph adenomas, research has shown that neither the overnight 1-mg dexamethasone suppression test nor the two-day low-dose dexamethasone suppression test appears to be reliable using the standard cutoffs for serum cortisol.

 

Thanks for posting this.

 

den

[MemberGone]

Thanks, Mary - I found this very interesting as well!

 

Glad to see the recognition, too, about the dex test not being the gold standard after all...and that some of us don't get elevated 24 hour ufcs. I didn't see a mention of the late night serum cortisol test, which was unfortunate, though.

[conti]

Thanks Mary.

 

Interesting read. It's for materisl like this that I hope endos around the world visit this forum and learn to open their mind.

 

 

Dave

[Kok]

I missed this when it was first posted.

 

Wow.

 

I was told that urinary frequency/incontinence could render a ufc impossible for me (and what the work around is) but to see it in print is altogether a different animal.

 

MaryO, I think this article and its links are really important. Would it be possible to post it elsewhere on the site (on the Endo News page or someplace like that).

 

They offer reprints.

 

I am very pressed for time right now but this reprint (4 color, easier to read) might be a great conversation starter for docs who are helping us but unsure.

 

I would gladly buy reprints from the cushie store ........... and will gladly do the footwork if it makes sense.

 

http://www.slackinc.com/reprints/

 

Thanks addflower.

 

[~MaryO~]

The article is on the (newest) site here: http://cushie.info/index.php?option=com_co...16:general-info and it will be in the next newsletter as a "Golden Oldie"

 

I can't really sell reprints since the original is owned by others, But you can print it from the website

[SusanM]

This article is disappointing. It appears that we are still in the dark ages --- Findlind indicates that in cases of 'mild' cushings the UFC may not be elevated. Ha! My pathology reports read differently and my body is now in shambles because of that thinking. In my opinion, this is an article to drum up some business.

[~MaryO~]

It was also published 9 months ago and who knows how long ago it was written before it was accepted and actually published.

 

A lot - thank goodness! - is happening with Cushing's research and information. Hopefully some doctors have read this and thought of Cushing's without dismissing it and sending another patient home with Valium and a diet plan.

 

It could be to drum up business, too - some doctors are definitely above that. I do hope that most wrote this with what they believed was correct info at the time.

 

(((Susan))) I hated that you had to write "my body is now in shambles because of that thinking" I wish things were better for you (and all of us!). It would be so much easier if this disease were cut and dried like a cold.

[ttiffany20191]

That was a really great article! I know they said that they will test many people for Cushings and only a few will have it but I think it is still important to test and screen people because it can be sooo devastating on the quality of life and your body. I wish it had been found sooner in myself because now it has a huge impact on me..

[peaches]

Thank you for posting this:)

[Kok]

MaryO, thank you for the links. Too bad about the reprints, makes sense though.