Jump to content

GH replacement in patients with non-functioning pituitary adenoma (NFA)


MaryO

Recommended Posts

  • Chief Cushie

From http://www.ingentaconnect.com/content/bsc/...000003/art00015

 

Authors: Arnold, J. R.; Arnold, D. F.; Marland, A.; Karavitaki, N.; Wass, J. A. H.

 

Source: Clinical Endocrinology, Volume 70, Number 3, March 2009 , pp. 435-438(4)

 

Publisher: Blackwell Publishing

 

 

 

Abstract:

 

Summary

 

Background

 

Subjects with non-functioning pituitary adenomas (NFAs) frequently develop GH deficiency due to tumour expansion or as a consequence of tumour therapy. The safety of GH replacement (GHR) in these individuals remains unclear.

 

Objective

 

To assess the effect of GHR on tumour recurrence in patients with NFAs solely treated by surgical removal.

 

Patients and methods

 

The study involved all patients with NFA who presented to the Department of Endocrinology in Oxford between January 1989 and July 2005 and were treated solely by surgical removal of the tumour. Patients with follow up < 1 year were excluded. Recurrence was diagnosed on the basis of radiological appearances (detectable tumour after gross total removal or regrowth of pre-existing residue) on regular imaging surveillance.

 

Results

 

One hundred and thirty patients were included in the study, and were followed up for a mean period of 6?8 ? 4?2 years (median 5?7, range 1?2-17?6). Twenty-three patients received GHR [16 male, 7 female, mean age at tumour diagnosis 53?7 ? 14?6 years (range 20-80)]. The mean duration of GHR was 4?6 ? 2?5 years (median 5?3, range 0?4-8?7). One hundred and seven subjects did not receive GH therapy [61 male, 46 female, mean age at tumour diagnosis 56?2 ? 14?0 years (range 20-87)]. Tumour regrowth occurred in 38 non-GH treated subjects (36%) and 8 GHR subjects (35%). Regrowth was detected at a mean of 4?8 ? 2?8 years (range 1-11 years) in the non-GH treated group, and at 6?5 ? 2?3 years in the GHR group. In the GHR group, recurrence occurred after a mean of 2?9 ? 2?2 years (range 0?4-5?9 years) following commencement of GH treatment. The Cox regression analysis showed that after adjusting for sex, age at tumour diagnosis, cavernous sinus invasion at diagnosis and type of tumour removal (partial or complete based on postoperative scan), GH treatment was not a significant independent predictor of recurrence (P = 0?09; hazard ratio = 0?51; 95% CI, 0?24-1?12).

 

Conclusion

 

GH replacement in patients with NFA treated by surgery alone is not associated with an increased risk of tumour recurrence.

 

Document Type: Research article

 

DOI: 10.1111/j.1365-2265.2008.03391.x

 

 

 

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

 

$42.40 plus tax

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...