Over 2000 Posts lydia Posted December 30, 2010 Over 2000 Posts Report Share Posted December 30, 2010 Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro CJ Auernhammer, GK Stalla, M Lange, A Pfeiffer and OA Muller Department of Medicine, University of Munich, Germany. Loperamide, an opiate agonist of high specificity for mu-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing's diseasehttp://jcem.endojournals.org/cgi/content/abstract/75/2/552 and this one (Ok, my new endo prof is in this abstract too) Patients with Cushing?s disease have a decreased GFR (glomular filtration rate in kidneys). Even if they are cured, close follow-up with strict control of cardiovascular risk factors and monitoring of GFR seems mandatory. Furthermore, the dosage of certain drugs should be adapted to the individual GFR. http://www.eje-online.org/cgi/content/abstract/153/6/819 Link to comment Share on other sites More sharing options...
This topic is now archived and is closed to further replies.