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symptoms returning after surgery 1 yr, and radiation 8 months

Guest Billp


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From what I understand, radiation can take up to 2 years to see results. I know plenty of folks here who had a failed pit surgery plus radiation. The majority of them went on to bilateral-adrenalectomy (bla) in order to get rid of cushings. In fact, after being here 6+ years I don't of one person that was truly helped by radiation.


How is your pit function now? What replacement hormones are you taking?




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Neuroendocrinology. 2010;92 Suppl 1:107-10. Epub 2010 Sep 10.

Pituitary radiotherapy for Cushing's disease.


Losa M, Picozzi P, Redaelli MG, Laurenzi A, Mortini P.




Department of Neurosurgery, Istituto Scientifico San Raffaele, Università Vita-Salute, Milano, Italy. losa.marco@hsr.it






The treatment of choice for Cushing's disease is pituitary surgery. Second-line treatments include repeat pituitary surgery, radiation therapy, medical therapy, and bilateral adrenalectomy. The most used modalities to irradiate patients with Cushing's disease include fractionated radiotherapy and single-dose Gamma Knife. We aim to review the efficacy and safety of radiotherapy in patients with persistent or recurring Cushing's disease.



Remission of Cushing's disease after radiotherapy ranges from 42 to 83%. There seems to be no clear difference according to the technique of radiation used. Most patients experience remission of disease within 3 years from treatment, with only few cases reaching normal cortisol secretion after a longer follow-up. Control of tumor growth varies from 93 to 100%. Severe side effects of radiotherapy, such as optic neuropathy and radionecrosis, are uncommon. New-onset hypopituitarism is the most frequent side effect of radiation, occurring in 30-50% of patients treated by fractionated radiotherapy while it has been reported in 11-22% of patients after Gamma Knife.



Radiotherapy is an effective second-line treatment in patients with Cushing's disease not cured by surgery. Consideration of the advantages and disadvantages of radiotherapy in comparison with other therapeutic options should always be carried out in the single patient before deciding the second-line therapeutic strategy for persisting or recurring Cushing's disease.

Copyright © 2010 S. Karger AG, Basel.


The full text article can be found at: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000314299&Ausgabe=254530&ProduktNr=223855&filename=000314299.pdf

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the site used a Varian Trilogy w brainlab? software. There have been no side effects. The only concern is after 7 months we had a reading of 115 urine cortisol after several months in the 30's. The race is on does the radiation work? The article indicates a 50/50 shot or 90% average in 3 years. It's unclear.

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