NIH Cushing's Clinical Trials

[~MaryO~]

From NIH (7/8/2008)

 

 

 

1

Recruiting

Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion Condition:

Cushing's Syndrome Intervention:

Drug: Mifepristone

2

Recruiting

Diagnostic Performance of Screening Tests for Cushing's Syndrome Condition:

Cushing's Syndrome Intervention:

 

 

3

Recruiting

A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Condition:

Cushing's Syndrome Intervention:

Drug: mifepristone

4

Active, not recruiting

Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome Condition:

Cushing's Syndrome Intervention:

 

 

5

Active, not recruiting

Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome Condition:

Cushing's Syndrome Intervention:

 

 

6

Completed

Long Term Post Operative Follow-Up of Cushing Syndrome Condition:

Cushing Syndrome Intervention:

 

 

7

Recruiting

New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome Condition:

Cushing Syndrome Intervention:

 

 

8

Active, not recruiting

Extension Study to Assess the Safety and Efficacy of Pasireotide in Patients With Cushing's Disease Condition:

Cushing Disease Intervention:

Drug: Pasireotide

9

Completed

Study of Cushing's Syndrome Not Related to ACTH Production Conditions:

Cushing's Syndrome; Healthy Intervention:

 

 

10

Recruiting

Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome Conditions:

Cushing's Syndrome; Insulin Resistance Intervention:

Procedure: Surgery

11

Recruiting

Study of Depression, Peptides, and Steroids in Cushing's Syndrome Condition:

Cushing's Syndrome Intervention:

 

 

12

Recruiting

Safety and Efficacy of Different Dose Levels of Pasireotide in Patients With de Novo, Persistent or Recurrent Cushing's Disease Condition:

Cushing's Disease Intervention:

Drug: Pasireotide

13

Completed

Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome Condition:

Cushing's Syndrome Intervention:

 

 

14

Active, not recruiting

A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease Condition:

Cushing's Syndrome Intervention:

Drug: SOM230 s.c.

15

Completed

Cognition, Steroids, and Imaging in Cushings Disease Condition:

Cushing Syndrome Intervention:

 

 

16

Completed

Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency Conditions:

Adrenal Gland Hyperfunction; Adrenal Gland Hypofunction; Cushing's Syndrome; Healthy Intervention:

Drug: Ovine Corticotropin-Releasing Hormone (oCRH)

17

Recruiting

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex Conditions:

Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm Intervention:

 

 

18

Recruiting

An Investigation of Pituitary Tumors and Related Hypothalmic Disorders Conditions:

Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm Intervention:

 

 

19

Recruiting

Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing's Disease) Condition:

Brain and Central Nervous System Tumors Interventions:

Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis

20

Recruiting

Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma Conditions:

Adrenocortical Carcinoma; Cushing's Syndrome Intervention:

 

 

21

Completed

Heart Disease Risk Factors in Major Depression Conditions:

Adrenal Gland Hyperfunction; Cardiovascular Disease; Involutional Depression Intervention:

 

 

22

Recruiting

Adrenal Tumors - Pathogenesis and Therapy Conditions:

Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma Intervention:

 

 

23

Recruiting

Adolescence, Puberty, and Emotion Regulation Conditions:

Mood Disorder; Neurobehavioral Manifestation; Healthy Intervention:

 

 

24

Completed

Dynamics of Leptin and Endocrine Function Conditions:

Healthy; Involutional Depression Intervention:

 

 

25

Recruiting

Study of Adrenal Gland Tumors Condition:

Adrenal Gland Neoplasm Intervention:

 

 

26

Completed

Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure Condition:

Addison Syndrome Intervention:

Drug: hydrocortisone substitution therapy versus withdrawal

27

Recruiting

Rosiglitazone in Treating Patients With Pituitary Tumors Condition:

Brain and Central Nervous System Tumors Intervention:

Drug: rosiglitazone maleate

28

Recruiting

Examination of Brain Serotonin Receptors in Patients With Mood Disorders Condition:

Mood Disorder Intervention:

 

 

29

Completed

Pharmacist Assisted Medication Program Empowering Regulation of Diabetes Condition:

Diabetes Mellitus, Type 2 Interventions:

Other: Pharmacist collaboration in diabetes care; Other: Usual care

30

Recruiting

A Study of rhuMAb IFNalpha in Adults With Systemic Lupus Erythematosus Condition:

Systemic Lupus Erythematosus Intervention:

Drug: rhuMAb IFNalpha

31

Recruiting

Etanercept for the Treatment of Lupus Nephritis Condition:

Lupus Nephritis Interventions:

Drug: Etanercept; Drug: Lupus Treatment

[Jo MacRaild]

Great info, thanks Mary..do you know if they have replaced the neuro there yet ?

[chanceofrain]

This is my opinion only, but I personally met with a few of the head investigators of the corlux study and wonder if this is going to be a beneficial study. If anyone is interested in joining this particular study please feel free to PM me to hear my opinion.