Tumors of the Pituitary Gland

[MaryOld]

[Official Title: Tumors of the Pituitary Gland and Associated Conditions:  A Genetic Investigation

 

Further Study Details:

 

    There is a variety of tumors affecting the pituitary gland.  The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible association with other developmental defects or inheritance pattern(s) has not been investigated.  The present study serves as a (i) screening/training, and (ii) a research protocol.

 

    As a screening and training study, this protocol allows our Institute to admit patients with tumors of the hypothalamic-pituitary unit to the clinics and wards of the NIH Clinical Center for the purposes of:  (i) training our fellows and students in the identification of gene defects associated with pituitary tumor formation, and (ii) teaching our fellows and students the recognition, management and complications of pituitary tumors.

 

    As a research study, this protocol aims at (i) developing new clinical studies for the recognition and therapy of pituitary tumors; as an example, two new studies have emerged within the context of this protocol:  (a) investigation of a new research magnetic resonance imaging (MRI) tool and its usefulness in the identification of pituitary tumors, and ( investigation of the psychological effects of cortisol secretion in pediatric only patients with Cushing disease.  Continuation of this protocol will eventually lead to new, separate protocols that will address all aspects of diagnosis of pituitary tumors and their therapy in childhood; and (ii) identifying the genetic components of pituitary oncogenesis; those will be investigated by (a) studying the inheritance pattern of pituitary tumors in childhood and their possible association with other conditions in the families of the patients, and ( collecting tumor tissues and examining their molecular genetics.  As with the clinical studies, the present protocol may help generate ideas for future studies on the treatment an clinical follow up of patients with tumors of the pituitary gland and, thus, lead to the development of better therapeutic regimens for these neoplasms.

 

Eligibility

   

Genders Eligible for Study: Both

   

Criteria

           

INCLUSION CRITERIA:

A. The following criteria must be met for all, who enter the study:

Age 3-70 years

Evidence for the existence of a tumor of the hypothalamic-pituitary unit, as indicated by previously obtained imaging studies or biochemical investigation of the hypothalamo-hypophyseal function.

Patients may withdraw from the study at any time.

B. For family members studied for linkage analysis, the following criteria must be met:

Any age

Member of a kindred suspected of having an inherited form of pituitary neoplasia, as evidenced by results of a patient studied under A (above).

   

Expected Total Enrollment:

1200

 

Location and Contact Information

   

Maryland

 

National Institute of Child Health and Human Development (NICHD), 9000 Rockville Pike  

   Bethesda,  

   Maryland,  

   20892,  

   United States; Recruiting

 

Patient Recruitment and Public Liaison Office, 1-800-411-1222

 

prpl@mail.cc.nih.gov

   

TTY 1-866-411-1010

 

   More Information

       

Detailed Web Page

   

Publications

 

Stratakis CA, Jenkins RB, Pras E, Mitsiadis CS, Raff SB, Stalboerger PG, Tsigos C, Carney JA, Chrousos GP.  Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex). J Clin Endocrinol Metab. 1996 Oct;81(10):3607-14.

 

Stratakis CA, Carney JA, Lin JP, Papanicolaou DA, Karl M, Kastner DL, Pras E, Chrousos GP.  Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest. 1996 Feb 1;97(3):699-705.

 

Schrock E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T.  Multicolor spectral karyotyping of human chromosomes. Science. 1996 Jul 26;273(5274):494-7.

 

Study ID Numbers

970076;

97-CH-0076

 

Date study started February 13, 1997

Record last reviewed, March 5, 2001

Last Updated, March 5, 2001

NLM Identifier  NCT00001595

ClinicalTrials.gov processed this record on 2002-04-23