Kristy

Thanks MaryO - I saw this in the lastest magazine from the PTNA. This is a really good easy to read and easy to understand publication about pituitary diseases. I don't know how many times I have searched the house for my 2nd edition!

Great Information - so that's why I can't remember!

ABSTRACT

Background Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive or restorative treatment.

Methods We carried out two 48-week, randomized, placebo-controlled studies of two doses of alendronate in 477 men and women, 17 to 83 years of age, who were receiving glucocorticoid therapy. The primary end point was the difference in the mean percent change in lumbar-spine bone density from base line to week 48 between the groups. Secondary outcomes included changes in bone density of the hip, biochemical markers of bone turnover, and the incidence of new vertebral fractures.

Results The mean (?SE) bone density of the lumbar spine increased by 2.1?0.3 percent and 2.9?0.3 percent, respectively, in the groups that received 5 and 10 mg of alendronate per day (PConclusions Alendronate increases bone density in patients receiving glucocorticoid therapy.

Source Information

N Engl J Med 1998; 339:292-299, Jul 30, 1998. Original Articles

I fixed the link. I guess they removed it from findarticles.com!

Thanks for sharing Kai! The article is very informative! For all those lurkers the Outline is:

 DOES THE PATIENT HAVE CUSHING'S SYNDROME?

   ? Pseudo-Cushing's syndrome

   ? Daily urinary cortisol excretion

   ? Low-dose dexamethasone suppression tests

   ? Late evening serum cortisol

   ? Late evening salivary cortisol

   ? CRH after dexamethasone test

   ? Naloxone test

   ? Insulin-induced hypoglycemia test

   ? Cortisol production rate

   ? Cushing's syndrome during pregnancy

   ? Recommendations

I'm so happy you took the time to share!

(Edited by Kristy at 10:22 pm on Sep. 7, 2001)

I'll add links as I come accross them.

This first one starts out talking about Alcoholism and withdrawal and the effects on the stress response. It does talk about how excess cortisol damages the brain.

http://www.niaaa.nih.gov/publications/arh2...7-72.pdf

This

http://www.cpa-apc.org/Subscri....(Edited by Kristy at 9:39 pm on Aug. 21, 2001)

This foundation offers tapes and books over all sorts of endocrine related health topics

http://www.brodabarnes.org/

I found the article at http://content.nejm.org/content/vol341/iss...dex.shtml

You

If I am correct, this type of adrenal hyperplasia is related to food induced cushings that weve been discussing in cyclical.

(Edited by Kristy at 3:11 pm on Sep. 12, 2001)

Hope all can use this!

http://www.freemedicaljournals.com/

These sites talk about pseudo-cushings:

http://www.niddk.nih.gov/health/endo/pubs/...gs/cushings.htm

www.pituitary.com/firstaid/disorders/Cushings.htm

A really great article that discusses distinguishing the states is The Diagnosis and Differential Diagnosis of Cushing?s Syndrome and Pseudo-Cushing?s States

John Newell-Price1, Peter Trainer, Michael Besser and Ashley Grossman. Endocrine Reviews 19 (5): 647-672

Copyright ? 1998 by The Endocrine Society

It can be found at

http://endo.endojournals.org/

If you cannot read the article, let me know. I can download it an e-mail.