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Pituitary adenoma


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http://doctors120.blogspot.com/2008/01/pit...adenoma_05.html

 

Saturday, January 5, 2008

Pituitary adenoma

 

Overview pituitary tumor (Pituitary adenoma) is a benign adenoma, very common, About 100,000 people that is l cases, there is a growing trend in recent years, particularly women of childbearing age.

 

Beijing Neurosurgical Institute report pituitary tumors accounted for 12.2% of intracranial tumors. Diagnosis of pituitary tumors are diagnosed according to clinical manifestations and Visual impairment and other neurological findings. and endocrine studies and radiology examinations, the typical pituitary tumor diagnosis is not difficult.

 

But in the early pituitary tumor, less obvious symptoms, diagnosis is not easy and may not even be found. Clinical manifestations of the pituitary endocrine organ containing several endocrine cells, the endocrine secretion of a variety of factors, If a certain endocrine cell adenoma growth may occur specific clinical performance. Details of each are described below :

 

1. Different types of pituitary adenomas endocrine performance

 

(1) growth hormone cell adenoma :
Early only a few millimeters of tumor size, mainly to excessive secretion of growth hormone. Minors patients growth can happen too quickly, and even grow into giants. After the adults for Acromegaly performance. If countenance change, the high forehead, prominent mandible, big noses and thick lips, fingers thick and wearing shoes and hats Cox tight, replace a larger number of models, even be specially produced, and some patients have increased appetite, hair, rough skin pigmentation and finger numbness. Severe sense of malaise, headache, joint pain, sexual dysfunction, infertility amenorrhea, or even with diabetes.

 

(2) prolactin-secreting pituitary adenomas :
The main performance of amenorrhea, galactorrhea, and sterility, severe shedding hair, pale skin delicate, Subcutaneous fat increased, and there are weak, easily tired, drowsiness, headaches, sexual dysfunction, and so on. Male performance for the loss of libido, impotence, breast hyperplasia, beards rare, severe genital atrophy, a decrease in the number of sperm, and sterility. Males Females were little changed.

 

(3) ACTH cell adenomas :
clinical manifestations of the physical concentric obesity moon face, buffalo back, more blood quality, abdominal skin with large purple leg stripes, like the increase in vellus hair. Severe amenorrhea, the loss of libido, malaise, or even bedridden. Some patients with hypertension, diabetes and so on.

 

(4) Thyroid Stimulating Hormone cell tumors :
rare, as pituitary thyroid stimulating hormone secretion over-caused symptoms of hyperthyroidism. In pituitary tumor removed after symptoms of hyperthyroidism disappeared. Another hypothyroidism feedback pituitary gland caused focal hyperplasia occurred gradually develop into a pituitary adenoma, After growing up can lead Sella expand nearby organizations oppressed symptoms.

 

(5) follicle stimulating hormone cell adenoma :
very rare, only individual clinical reports of sexual dysfunction, amenorrhea, infertility, reducing the number of sperm.

 

(6) melanin stimulating hormone cell adenoma :
very rare and only some individual reports of patients calmly black skin, not with cortisol increased.

 

(7) endocrine function inactive adenoma :
Early patients without tumor grew up feeling special, to be oppressed pituitary pituitary insufficiency of clinical manifestations.

 

(8) malignant pituitary tumor :
a short history, the disease progress faster is not just a pituitary tumor growth suppression, and to the surrounding violations, to saddle the end of bone destruction or immersion cavernous caused oculomotor nerve palsy or outreach nerve palsy. Sometimes saddle tumor broke through to the end of a long transsphenoidal within a short period of time not to neurological symptoms significantly.

2. Visual obstacles : Early pituitary adenoma often without visual interference. If the tumor grew up, stretching upward, as the intersection of oppression, we have a visual field defect, the upper outer quadrant first affected, Red vision first shown. After the lesions increased oppression heavier, white vision are also affected defect can be gradually expanded to a double-temporal hemianopsia. If not treated in time, the visual field defect can be expanded and the eyesight has deteriorated, and the resulting blind. Because many pituitary tumors are benign, sustainable very early lesions time to be in serious condition, Visual barriers can suddenly increased, and if the tumors tend to side, to be Blind or monocular blindness.

 

3. Other neurological signs and symptoms : If back on the pituitary tumor growth suppression of pituitary stalk or hypothalamus, multiple drink polyuria; If the lateral side of tumor growth cavernous wall violations, occur or outreach oculomotor nerve palsy; If the tumor through the saddle diaphragm upward to the growth of the ventral frontal, sometimes psychotic symptoms; If the tumor grew back obstruction in front of the third ventricle and the room between holes, headache and vomiting, and other symptoms of increased intracranial pressure; If the tumor growth back, brainstem compression to coma, paralysis or brain tonic to such.

 

Posted by doctor at 6:21 PM

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