Chief Cushie ~MaryO~ Posted November 30, 2006 Chief Cushie Report Share Posted November 30, 2006 http://neuro.psychiatryonline.org/cgi/cont...stract/18/4/450 J Neuropsychiatry Clin Neurosci 18:450-459, November 2006 doi: 10.1176/appi.neuropsych.18.4.450 ? 2006 American Psychiatric Publishing, Inc. Special Article The Neuropsychiatric Profile of Addison?s Disease: Revisiting a Forgotten Phenomenon Rebecca E. Anglin, B.Sc., M.D., Patricia I. Rosebush, M.Sc.N., M.D., F.R.C.P.(C.) and Michael F. Mazurek, M.D., F.R.C.P.(C.) Received November 2, 2005; revised January 8, 2006; accepted January 19, 2006. Drs. Anglin and Mazurek are affiliated with the Department of Medicine and Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada. Dr. Rosebush is affiliated with the Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada. Address correspondence to Dr. Rosebush, 3G15, Health Sciences Center, 1200 Main St.W, Hamilton, Ontario, L8Z 3N5, Canada; email@example.com (E-mail). One hundred fifty years since Thomas Addison?s original description of the disease, it is not commonly appreciated that patients with Addison?s disease may present with psychiatric symptoms. A review of the literature indicates that disturbances in mood, motivation, and behavior are associated with Addison?s disease. Psychosis occurs less frequently, but can be the presenting symptom of a life-threatening adrenal crisis. Potential mechanisms for the neuropsychiatric symptoms of Addison?s disease include electrophysiological, electrolyte and metabolic abnormalities, glucocorticoid deficiency, increased endorphins, and an associated Hashimoto encephalopathy. Physicians must be aware that Addison?s disease may present solely with psychiatric symptoms and maintain a high index of suspicion for this potentially fatal condition. ~~~~~~~~~~~ You may access this article (from the computer you are currently using) for 1 day for US$15.00 at http://neuro.psychiatryonline.org/cgi/reprint/18/4/450 Quote Link to comment Share on other sites More sharing options...
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