Chief Cushie ~MaryO~ Posted April 17, 2008 Chief Cushie Report Share Posted April 17, 2008 http://jcem.endojournals.org/cgi/content/a.../jc.2008-0368v1 This version published online on April 15, 2008 Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2008-0368 Submitted on February 14, 2008 Accepted on April 4, 2008 Aerobic Capacity and Growth Hormone Deficiency after Traumatic Brain Injury Kurt A. Mossberg*, Brent E. Masel, Charles R. Gilkison, and Randall J. Urban Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX; Transitional Learning Center, Galveston, TX; Department of Medicine, University of Texas Medical Branch, Galveston, TX * To whom correspondence should be addressed. E-mail: firstname.lastname@example.org Context: Growth hormone (GH) deficiency occurs in approximately 20% of all individuals who suffer from a moderate to severe traumatic brain injury. Objective: This study determined whether GH deficiency secondary to traumatic brain injury had an effect on aerobic capacity. Design: Subjects were screened for growth hormone deficiency by the glucagon stimulation test and performed a maximal treadmill exercise test. Setting: Patients were studied in the post-acute recovery phase after traumatic brain injury. Participants: Thirty-five individuals were studied. Groups were formed as follows: normal GH axis ? greater than 8 ng/mL response (n=12), insufficient ? GH 3-8 ng/mL response (n=11), and deficient ? less than 3 ng/mL response (n=12). Intervention: None. Main Outcome Measure: Aerobic capacity was assessed by measuring expired gases during a graded treadmill exercise test. One-way and two-way analyses of variance (ANOVA) were carried out on all peak and submaximal cardiorespiratory variables, respectively. Appropriate post hoc comparisons followed as necessary. Results: Significantly higher peak VO2 was found in traumatic brain injury subjects with GH normal versus GH insufficient and deficient (26.4 ? 6.9, 20.8 ? 4.6 and 19.7 ? 5.0; respectively (p<0.05)). Submaximal VO2 was significantly higher in the GH normal group. All other variables were statistically similar. Conclusions: This study shows that individuals with traumatic brain injury with normal GH secretion have below normal aerobic capacity and those patients who have GH insufficiency/deficiency are further deconditioned. Studies of GH replacement in these subjects should be conducted to assess whether GH therapy can improve cardiorespiratory fitness and prevent secondary disability Link to comment Share on other sites More sharing options...
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