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Seismic study for mifepristone? clinical study at OHSU?


Robert

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Is anyone planning to participate in the Seismic clinical study, or know much about it? We've heard it will be starting at OHSU in Portland, OR soon (October or November 2008), apparently using the drug Mifepristone (also known as RU486). any known concerns or good results?

 

Robert

email: kbrown_4@comcast.net

 

...or anyone interested to talk by phone, or meet in Vancouver, WA or Portland, OR area sometime....

 

history:

51 year old male, good health until 2004, then tiredness, multiple symptoms, but not diagnosed until fall 2005 with

Cushing's Disease

pituitary ademoma, surgery Dec. 2005, couldn't get it all

33 radiation treatments spring 2006

Oct. 2008: still on ketoconazole, still overweight and signs of Cushing's, considering the clinical study.....

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It's a drug that shuts off your adrenal glands, much like ketoconazole but stronger. I believe it's an option for people who can't take keto or for whom it doesn't work. Not sure why they're doing a clinical study about it though, I thought it was already approved for this use...

 

 

 

 

 

Is anyone planning to participate in the Seismic clinical study, or know much about it? We've heard it will be starting at OHSU in Portland, OR soon (October or November 2008), apparently using the drug Mifepristone (also known as RU486). any known concerns or good results?

 

Robert

email: kbrown_4@comcast.net

 

...or anyone interested to talk by phone, or meet in Vancouver, WA or Portland, OR area sometime....

 

history:

51 year old male, good health until 2004, then tiredness, multiple symptoms, but not diagnosed until fall 2005 with

Cushing's Disease

pituitary ademoma, surgery Dec. 2005, couldn't get it all

33 radiation treatments spring 2006

Oct. 2008: still on ketoconazole, still overweight and signs of Cushing's, considering the clinical study.....

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I think mifepristone works by upregulating steroid receptors in number and sensitivity, thereby reducing the need for excess cortisol. Interestingly, it quickly reverses bipolar disorder, depression and even psychoses in those with high cortisol induced mental illnesses.

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